Study on 1, 3, 4-Oxadiazole Derivatives as an Antibacterial and Antifungal Agents

A new series of 1, 3, 4-oxadiazoles (3a-j) was synthesised in this study by reacting INH (1) with substituted aromatic acids (2) in the presence of POCl3. IR, 1H NMR, and mass spectrum data were used to identify the novel compounds. In-vitro antibacterial and antifungal properties were tested on the compounds, and they were compared to standard medications. Some of the chemicals tested were effective against all of the species. The presence of electron-donating and electron-withdrawing groups in the fourth position is primarily responsible for the high activity.

Author (S) Details

B. C. Revanasiddappa
Department of Pharmaceutical Chemistry, NGSM Institute of Pharmaceutical Sciences (NGSMIPS), Nitte (Deemed to be University), Mangalore-575018, (Karnataka), India.

V. S. Subrahmanyam
Department of Pharmaceutical Chemistry, NGSM Institute of Pharmaceutical Sciences (NGSMIPS), Nitte (Deemed to be University), Mangalore-575018, (Karnataka), India.

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