Urinary Uric Acid to Urinary Creatinine Ratio- A Very Promising Biochemical Marker for Perinatal Asphyxia!!!

Background: Perinatal asphyxia is one of the most common disorders in newborns, and it contributes significantly to neonatal morbidity and mortality. It’s a well-known and important cause of avoidable cerebral damage. Predicting the result of prenatal asphyxia is crucial, but it’s also a nightmare. The Apgar score has a limited significance in forecasting immediate outcomes, such as HIE, and observational error in APGAR can lead to long-term neurological consequences. The biochemical parameters, on the other hand, can be trusted. Asphyxia diagnosis and grading can be difficult, especially if crucial information is not available at the time of delivery. The goal of this study was to see if the urine uric acid/creatinine ratio (UA/Cr) could be used as a non-invasive marker for prenatal hypoxia and if its absolute value might be linked to the severity of the condition.

  1. To establish the Urinary Uric Acid to Urinary Creatinine Ratio as a perinatal asphyxia marker.
  2. To establish the ratio of urinary uric acid to urinary creatinine as a measure of prenatal hypoxia severity.
  3. To establish a cut-off value for the ratio of urinary uric acid to urinary creatinine in order to detect foetal asphyxia.

Methods: This prospective case control study was conducted at the Pediatrics Department of Shri Ram Murti Smarak Institute of Medical Sciences between November 2017 and May 2019. It included 42 asphyxiated and 42 non-asphyxiated newborns. All of the neonates who were enrolled underwent a thorough examination and history. Urine samples were sent in to be tested for uric acid and creatinine. The results were noted, and a statistical analysis was performed.

The uric acid to creatinine ratio in the urine is a non-invasive, early, and simple biochemical measure of birth hypoxia that biochemically supports severity grading and clinical diagnosis by the APGAR score.

Conclusions: The urinary uric acid and creatinine ratio can be used to diagnose asphyxial injury quickly and accurately, as well as determine its severity and likelihood for short-term morbidity or fatality.

Author(S) Details

Siddharth
Department of Pediatrics, SRMS IMS, Bareilly, Uttar Pradesh, India.

Preeti Lata Rai
Department of Pediatrics, SRMS IMS, Bareilly, Uttar Pradesh, India.

P. L. Prasad
Department of Pediatrics, SRMS IMS, Bareilly, Uttar Pradesh, India.

View Book:- https://stm.bookpi.org/RDMMR-V4/article/view/4182

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