Calculation of MTDSC Signals, Factors Effecting the Signals and Applications in Drug Development: A Recent Study

In this paper, the author discusses the fundamentals of Modulated Temperature Differential Scanning Calorimetry (MTDSC), the advantages of MTDSC over conventional DSC, the calculation of heat flow and heat capacity components, factors affecting MTDSC signals, and MTDSC application in drug development. A sinusoidal modulation is overlaid on top of a standard linear heating ramp in MTDSC, which raises the sample temperature steadily over time.

The sinusoidal heating rate determines the fraction of total heat flow that corresponds to the changing heat rate, whereas the linear heating rate delivers the same information as a standard DSC. Heat capacity and heat capacity change determine the overall heat flow rate. A portion of heat flow is reversing heat flow, often known as the heat capacity component of total heat flow. Because it does not adjust to changes in the heating rate, the kinetic component is also known as non-reversing heat flow. For accurate measurements of heat flow and heat capacity components, optimal experimental parameters must be adopted. MTDSC is used in preformulation studies to determine Tg, polymorphic forms, and polymorphic transitions, as well as to ensure stability by performing drug excipient compatibility testing and calculating the enthalpy of polymorphic transitions.

Author(S) Details

Urmila Sri Syamala
Arnold and Marie Schwartz College of Pharmacy, LIU, Brooklyn, NY, USA.

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