Thyroid and Growth Hormones Interdependence and Their Synergistic Effect on Growth and Development at Childhood

The goal of this study is to see how variations in thyroid and growth hormone plasma levels affect physical growth indices, as well as how these hormones change with age in children aged 6 to 10.

Design of the Study: The research is a prospective study that aims to find out how differences in growth and thyroid hormones affect children’s physical growth and development.

Methodology: The study’s 180 subjects (males 81 and females 99) had their anthropometric uniqueness described and their BMI calculated. The youngsters were divided into age groups of 6, 7, 8, 9, and 10 years. Thyroid and growth hormones were measured using a STAT FAX 303 microtitre plate reader and an Enzyme-Linked Immunosorbent Assay (ELISA) unique for each hormone. The statistical package SPSS version 23.0 (SPSS, Chicago, IL, USA) was used for statistical analysis, data management, and statistical analyses. Student’s t-test was used to determine group differences, ANOVA was used to find group variations, and Pearson’s correlation was used to determine the link between parameters. The association between hormone concentrations and the ages of the children was charted using Excel. The tests’ significance level was set at 0.05. The results will be presented as Mean Standard Deviation (SD).

Results: Nineteen percent (n=34) had GH values of less than 0.6 ng/ml, 64 percent (n=115) had values ranging from 0.6 to 10.0 ng/ml, and 17 percent (n=31) had values greater than 10.0 ng/ml. Thyroid stimulating hormone (TSH) values ranged from 0.35-8.44 Iu/ml in 92% of the children (n=166); 6.1 percent (n=11) had values >8.44 Iu/ml, which are above normal, and 1.7 percent (n=3) had values 0.35 Iu/ml, which are below normal. Triiodothyronine tends to increase from birth, peaking within the first year of postnatal life, and then gradually reducing to adult levels, whereas GH appears to increase from birth, peaking around the age of nine, and then gradually declining to adult levels. Children with an apparent GH shortage had significantly greater T3 and T4 levels and reduced TSH, while those with high GH levels had low T3 and T4 levels and a high TSH. TSH and growth hormones had negative correlation coefficients in individuals with high and low GH (r=-0.05 and r=-0.130), respectively, whereas TSH and GH had a positive connection coefficient (r=0.093) in those with normal GH. Physical growth indicators, however, were preserved across the board.

Conclusion: The study found that growth failure can be caused by the failure of both hormones, and that it is unlikely to occur throughout childhood when there is an unbroken synergy between thyroid and growth hormones.

Author(S) Details

Raymond Ekong Eworo
Department of Medical Laboratory Science, College of Medical Sciences, University of Calabar, Calabar, Nigeria.

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