Impact of Highly Active Antiretroviral Therapy (HAART) on Some Immunological Indices and Quality of Life of HIV Positive Patients in Africa

HIV infection is one of the most widespread pandemics, with an estimated 79.3 million people infected worldwide. It posed a threat to humanity’s survival due to its high mortality and morbidity. This was before the development of an efficient virus-replication-inhibiting medication. HAART, or highly effective antiretroviral therapy, is a significant development in the treatment of HIV-positive people. Individuals’ lives have been changed by combination therapy, which has improved their quality of life. In Sokoto, Nigeria, researchers looked at the influence of HAART on some immunological indices (CD4 T-cells and WBC count) as well as the quality of life of an HIV positive (patients) cohort. The study enlisted 200 samples, including 50 controls, 50 HAART naive, 50 on HAART for 1-6 months, and 50 on HAART for 7-12 months. Cassens et al. (2004) created a flow cytometry method to quantify CD4 T cells, whereas Cheesbrough devised a method to measure WBCs (2010). When compared to the control subjects, HIV positive patients have significantly lower levels of CD4 T-cells and WBC count (P0.05). When compared to the other two HIV positive groups, individuals on treatment for 7-12 months had considerably greater levels of both parameters. The duration of treatment has an effect on the level of the two parameters. The findings imply that HAART improves CD4 T-cell and WBC counts in HIV patients, which has a positive influence on their life. As a result, HIV positive people on long-term HAART treatment may have their levels of the two immunological indices return to normal, improving their physical, psychological, social, and spiritual well-being.

Author(S) Details

M. M. Abduljalil
Central Advance Science Laboratory Complex, Usmanu Danfodiyo University, Sokoto, Nigeria.

R. A. Umar
Department of Biochemistry, Usmanu Danfodiyo University, Sokoto, Nigeria.

M. G. Abubakar
Department of Biochemistry, Usmanu Danfodiyo University, Sokoto, Nigeria.

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