Sildenafil increases endometrial growth by relaxing the smooth muscles of blood vessels, inducing vasodilation. One of the mainstays of infertility treatment is increasing endometrial thickness. The purpose of this study is to see how Sildenafil affects endometrial characteristics during the ovulation induction cycle.
Materials and Procedures: A total of 50 infertile women with thin endometrium were randomly assigned to one of two groups. 25 women in Group A received clomiphene citrate 50 mg daily from D2 to D6, as well as estradiol valerate 2 mg thrice daily from D2, and 25 women in Group B received clomiphene citrate 50 mg daily from D2 to D6, estradiol valerate 2 mg thrice daily from D2, and sildenafil citrate 25 mg vaginally thrice daily from D7 to the day of ovulation trigger. Trans-vaginal ultrasound was used to evaluate follicular development and endometrial features on alternate days beginning on day 8 of the cycle. An HCG trigger was given once the dominant follicle was >18 mm. In total, three ovulation cycles were investigated.
Endometrial character monitoring demonstrated a considerable improvement in Group B in all ovulation-induced cycles.
The mean endometrial thickness in Group B was 10.21.6 mm versus 8.531.4 mm in Group A; the tri laminar pattern was 93.54 percent in Group B versus 40.29 percent in Group A; the zone 4 endometrium was 79.03 percent in Group B versus 26.86 percent in Group A; and the clinical pregnancy rate per cycle was 20.96 percent in Group B versus 13.45 percent in Group A.
Conclusion: In ovulation induction cycles, the addition of vaginal Sildenafil to estradiol valerate has a substantial effect on endometrial features and clinical pregnancy rates.
Alla Satyanarayana Reddy
Department of Obstetrics & Gynaecology, Vinayaka Mission`s Research Foundation (DU), Vinayaka Mission`s Medical College, Karaikal, India.
A. Vikram Arun
Department of Radiology, Vinayaka Mission`s Research Foundation (DU), Vinayaka Mission`s Medical College, Karaikal, India.