Studies on Low Dose Magnesium Sulfate in Eclampsia in a Tertiary Care Hospital

Eclampsia is a serious obstetric condition that can result in substantial morbidity and even death in both the mother and the infant. The Pritchard regimen is a well-known anticonvulsant method that has been found to work in the treatment of eclampsia. In low-weight Indian women, a low-dose MgSO4 regimen is being investigated to reduce MgSO4 toxicity. The low dose protocol includes a loading dose of 4 gm MgSO4 slow IV, followed by a maintenance dose of 2 gms MgSO4 slow IV every three hours; continued for 24 hours after delivery or 24 hours after the last convulsion, whichever comes first; if a convulsion occurs during treatment, an additional dose of 2 gms MgSO4 slow IV is given in addition to the regular dose.

Eclampsia was detected in 123 women between 2017 and 2018. 69 women were admitted to the hospital with eclampsia, 15 of whom developed eclampsia after admission, and 39 women were referred to other hospitals for treatment. 60 percent of the women had antenatal or antepartum eclampsia. Postpartum eclampsia struck one-third of the mothers, while intrapartum eclampsia struck the rest. A blood pressure of less than 160/110 mm Hg was found in 40% of women, whereas a blood pressure of more than 160/110 mm Hg was found in 60%. At or after 37 weeks, two-thirds of the 81 direct admissions developed eclampsia; 60% had an unaided vaginal delivery; 1/6 had an instrumental vaginal delivery; and 1/4th of the women were terminated by LSCS. Thirteen of the 81 women had absent FH, five had intrapartum foetal death, 90 percent of the 63 live deliveries had a fair Apgar score, 10% had a bad Apgar score at 5 minutes of delivery, and three babies died prematurely. One woman suffered from eclampsia and had ten fits before collapsing and dying. Others are on the verge of being released. Pritchard’s low-dose MgSO4 regimen is just as effective. When compared to the Pritchard regimen, the low dose regimen had similar maternal and foetal morbidity and death rates.

Author(S) Details

Alla Satyanarayana Reddy
Department of Obstetrics& Gynaecology, Vinayaka Mission`s Research Foundation(DU), Vinayaka Mission`s Medical College, Karaikal, India.

Manjula Sivaramakrishnan
Department of Obstetrics& Gynaecology, Vinayaka Mission`s Research Foundation(DU), Vinayaka Mission`s Medical College, Karaikal, India.

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