Study on Phytoestrogen and Gut Micro-Biome Composition of Women with PCOS

PCOS (polycystic ovarian syndrome) is a prevalent endocrine condition that affects up to 15% of women in their reproductive years. Clinical symptoms of affected women include ovulatory failure, insulin resistance, hyperandrogenism, and obesity. Although the aetiology of PCOS is still unknown, various research investigations have shown that genetic and lifestyle variables have a role in its development. However, the specific pathophysiology of the disease must be established. The gut microbiota has a significant impact on human health. Women with PCOS have been found to have a dysbiotic gut microbiome and changed gut microbiome makeup. Phytoestrogen, for example, is a plant-derived nutritional bioactive molecule that has a structure and function similar to oestrogen hormone. It helps to relieve the symptoms of PCOS without having any negative side effects, such as improving ovulation and lowering blood glucose levels. It also improves the composition of the gut microbiome by enhancing alpha and beta diversity. The major goal of this chapter is to look into the numerous studies that have been done on the relationship between phytoestrogens, PCOS, and gut microbiome makeup.

Author(S) Details

K. Gayathri
Department of Clinical Nutrition, Sri Ramachandra Faculty of Allied Health Science, Sri Ramachandra Institute of Higher Education and Research (DU), Chennai-116, India.

V. Supriya
Department of Clinical Nutrition, Sri Ramachandra Faculty of Allied Health Science, Sri Ramachandra Institute of Higher Education and Research (DU), Chennai-116, India.

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