Analysing the Epidemiological Factors and Biological Markers of Rheumatoid Arthritis

Background: In the management of rheumatoid arthritis, early diagnosis is crucial since it allows for timely intervention and a better prognosis. With the goal of early identification and reduced morbidity, a prospective study was done to evaluate epidemiological aspects and molecular indicators of rheumatoid arthritis, as well as NEW ACR 2010 criteria and DAS28.

Methods and Materials: This study comprised 62 patients between the ages of 21 and 75 years old with varied rheumatoid arthritis complaints who met the revised ACR 2010 criteria. Age and gender distribution, disease duration, seasonal fluctuation, socioeconomic level, pain in various joints, deformity presentation and interval from disease beginning, several biological markers (RA factor, antiCCP), disability score (das28), and VAS were all noted.

The condition was most usually identified within 24 months after beginning and during the winter. The most prevalent age group was 41-50 years, with a female-male ratio of 4:1. The most typical pattern of joint involvement was Wrist and MCP > PIP > Elbow, Shoulder, and Knee > Ankle >Cervical >Lumbar spihe. 69.35 percent of patients showed DAS28 joint involvement, while 19.36 percent had typical deformity. Anti-CCP was found in 72.7 percent of RA factor negative cases and 64.52 percent of RA factor positive cases. The average DAS28 score was 7.38, with 53.23 percent scoring a 9 on the NEW ACR 2010.

Conclusion: Anti-CCP can be used to diagnosis RA negative cases, but when paired with the DAS28 and NEW ACR 2010 scores, the accuracy of diagnosing rheumatoid arthritis improves, allowing for early treatment and better outcomes.

Author(S) Details

Sanjay Kumar
GSVM Medical College, Uttar Pradesh, India.

Ajay Bharti
GSVM Medical College, Uttar Pradesh, India.

A. K. Gupta
GSVM Medical College, Uttar Pradesh, India.

Hemraj Saini
GSVM Medical College, Uttar Pradesh, India.

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