Discrimination Of Various Brain Pathological Lesions Non-invasively by MRI Utilizing Supervised Machine Learning Manipulating Tissue Refractive Index, T2 Relaxation Values and Tissue Metabolites

For the stability of dental implants and artificial joints, excellent solid bonding between biomaterials and bone tissue (osseointegration and osteo-conductivity) is critical. Much has been learnt about this notion, leading to substantial advances in implant design and surface modification in the fields of implant dentistry and orthopaedic surgery.

We studied whether low-intensity pulsed ultrasound (LIPUS) could accelerate the osseointegration ability of bioactive materials such as bioactive titanium and hydroxyapatite for this issue.

Bio-active pure titanium and hydroxyapatite (HA) were used as materials, and an in vitro simulation test and an animal experiment were conducted.

The production of bone-like hydroxyapatite on the material surface in simulated body fluid (SBF) under LIPUS was evaluated in a simulation test. The bio-active samples implanted to the rabbits’ femurs, which underwent LIPUS irradiation, were studied using Scanning Electron Microscope (SEM), X-ray diffraction (XRD), and histological observation in an animal test.

As a result of the crystal growth of bone-like apatite on the surface of the sample materials, LIPUS irradiation showed excellent enhancement of bone-material attachment, implying that LIPUS application has clinical potential to improve osseointegration (osteointegration), bone-bonding ability of bio-active materials.

Author(S) Details

Tapan K. Biswas
Department of Instrumentation and Electronics Engineering, Jadavpur University, India.

Rajib Bandyopadhyay
Department of Instrumentation and Electronics Engineering, Jadavpur University, India.

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