Determining the Anti-Inflammatory and Anti-Microbial Activity of Chalcone from Dalbergia sissoo Roxb. Leaves

The isolation and characterization of a chalcone or okanin [(E)-3-(3,4-dihydroxyphenyl)-1-(2,3,4-trihydroxyphenyl) prop-2-en-1-one] has been disclosed in this paper. Bio-assay-guided fractionation was used to isolate the cells. Methanol, hexane extracts, and isolated okanin from methanol extracts all had antibacterial action against gramme positive (Micrococcus luteus and Staphlococcus aureus) and gramme negative bacteria (Escherichia coli, R. planticola and Acinetobacter). Hexane extracts, methanol extracts of Dalbergia sisso Roxb, and okanin have all been examined for their anti-inflammatory properties. The methanolic extract was the most active. Dalbergia sissoo dried leaves have antibacterial, antiprotozoal, and anti-inflammatory properties. This is the first time a chalcone from the genus Dalbergia has been discovered. The discovery shows that more research is needed to determine the presence of novel phytoconstituents.

Author(S) Details

Padma C. Behera
Department of Pharmaceutical Sciences, Jharkhand Rai University, India.

S. M. Verma
Department of Pharmaceutical Sciences, Jharkhand Rai University, India.

Posa Mahesh Kumar
Department of Pharmaceutical Sciences, Jharkhand Rai University, India.

Nalin B. Das
Bioresource and Engineering Department, Institute of Minerals & Materials Technology (CSIR) Bhubaneswar 751013, Orissa, India.

Pravat M. Mishra
Bioresource and Engineering Department, Institute of Minerals & Materials Technology (CSIR) Bhubaneswar 751013, Orissa, India.

Sasmita Baliarsingh
Gandhi Engineering College, Bhubaneswar 751013, Orissa, India.

Hemendra Mishra
Department of Pharmacy, Jharkhand Rai University, India.

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