Bio Active Solvent Free Synthesis of 7,7-dimethyl-4-Phenyl -Tetra Hydro Quinazaloine-(1H,3H)- 2,5-Diones Derivatives Employing Methanesulfonic Acid

Due to its broad variety of biological activities, such as antibacterial and fungicidal activity, the synthesis of 7,-dimethyl-4-phenyl tetrahydroquinazalones- (1H, 3H)-2, 5-diones derivatives has received a lot of attention. The current investigation of an efficient and cost-effective method for the synthesis of 7,7-dimethyl-4-phenyl tetrahydroquinazalones-(1H,3H)-2,5-diones derivatives using dimedone, urea, and substituted aromatic aldehyde using Methanesulfonic acid as catalyst under solvent free conditions is part of our research work in this area. Chemical, analytical, and spectral investigations were used to characterise and structurally elucidate the products. 1H-NMR and 13CNMR spectroscopy, as well as mass spectral and elemental analysis, were used to examine the newly synthesised compounds. Various strains were used to test the antimicrobial capabilities of the named compounds, which showed mild to moderate antibacterial and antifungal activity.

Author (s) Details

Chinnayya Setty
Department of Chemistry, Gitam University, Visakhapatnam India.

N. Krishnarao
Department of Chemistry, PRISM DG&PG College, Andhra University, Visakhapatnam, India.

B. V. Durgarao
Department of R&D, ONGC, Rajahmundry, India.

V. Narasingrao
Department of Microbiology, PRISM DG&PG College, Andhra University, Visakhapatnam, India.

P. Ramalakshmi
Department of Microbiology, PRISM DG&PG College, Andhra University, Visakhapatnam, India.

Shaik Lakshman
Department of Chemistry, Gitam University, Visakhapatnam India.

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