Study on Diabetes Complications: A New Perspective on the Mechanism of Their Development

Diabetes problems affect organs with microcirculation (brain, eye, heart, kidney, and skin), which are where the body’s glucose-fueled energy production occurs. Changes in the quantity and quality of equilibrated blood affect energy production in cells in the microcirculation. The body’s response to these alterations is what leads to the development of diabetes complications. The buildup of advanced glycation end products and/or activation of their downstream signaling pathways are linked to many of the pathogenic pathways known to mediate diabetes consequences.

When the volume of equilibrated blood is diminished as a result of vasoconstriction in the microcirculation, long-term chronic diabetic problems arise. Organ damage and malfunction occur as a result of the remedial actions needed to optimize energy production – a diabetes complication. Patients with diabetes insipidus and diabetes mellitus are both affected by these consequences.

“Hypo” and “Hyper” are problems that are unique to diabetics. They are the body’s attempt to change the quality of the microcirculation’s equilibrated blood.

Insulin shortage disrupts the glucose/glycogen balance, which maintains a steady glucose concentration in the blood plasma. As a result, the blood glucose content in the body swings wildly from its balance. Low glucose concentration causes “hypo,” while high glucose concentration causes “hyper.”

It has been demonstrated using the new polyuria paradigm that diabetic problems are caused by the body’s resistance to interference in the glucose-fueled energy production process in microcirculated organs.

Author(S) Details

Owusu Akyiaw Bempah
FV Supplement Ltd., 362 Summerwood Road, Isleworth-Middlesex, United Kingdom

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