Determination of Solid Dispersion by Fluidized Bed Processing: A Platform for Enhancement of Solubility and Dissolution

This comprehensive article discusses fluidized bed processing as a novel way for improving the solubility of pharmaceuticals that are insufficiently water-soluble. The major goal of this research was to use the fluidized bed processing technique to investigate the solubility and dissolution kinetics of the poorly water-soluble medication simvastatin from its solid dispersion with various carriers. Drug solubility is one of the most critical barriers to achieving desired medication convergence in the blood. Around 40% of all new and existing medicine up-and-comers are lipophilic in nature and fail to reach useful levels due to poor solubility, resulting in sluggish dissolution and inadequate bioavailability. The drug characteristics, ingestion site, and needed dose structure attributes all influence which solubility upgrade process is used. Simvastatin is BCS class- II, meaning it is poorly soluble and permeable, reducing its bioavailability. To address this issue, a solid dispersion is created using various techniques with a polymeric carrier to potentially improve solubility and dissolution rate, such as fluidized bed processing. This will increase drug absorption, so the goals were to compare different solid dispersions and assess the effect of various carriers in extending drug absorption. In order to boost the bioavailability of weakly water-soluble medicines, Gelucire® 44/14, PVP- K30, and Poloxamer were used as carriers. The dissolution profiles were associated using a variety of mathematical models, including zero order, first order, Higuchi, and Hixon Crowell, with the Zero order kinetics model outperforming the others. When compared to the pure medication and alternative carriers, the dissolution profile of SIM was greatly enhanced when complexed with Gelucire 44/14. The dissolving rate and solubility profile of the binary system produced with FBP were the greatest. It was also discovered that all SIM SDs had a much higher dissolution rate and solubility than both PMs, and that the dissolution rate of both PMs was higher than pure simvastatin.

Author(S) Details

Rajendra K. Surawase
Loknete Dr. J. D. Pawar College of Pharmacy, Manur, Kalwan, Nashik, MS, India.

Kamalkishor G. Baheti
Maulana Azad Educational Trust’s Y. B. Chavan College of Pharmacy, Aurangabad, MS, India.

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