Evaluation of Hepatoprotective Activity of Vitex negundo Linn. against Paracetamol Induced Hepatotoxicity in Rats

The purpose of this study was to determine the hepatoprotective efficacy of an ethanolic extract of Vitex negundo Linn leaves. Vitex negundo Linn. is a medicinal plant that can be found all across India. It is a short Mediterranean plant that is utilised as a folkloric herbal treatment.

Methods: The ethanolic extract of Vitex. Negundo Linn. (300 mg/kg) was given orally to the rats with hepatotoxicity caused by paracetamol (3 gm/kg) hepatotoxicity. The reference standard was silymarin (25 mg/kg). Histopathological investigations of liver tissue backed up the hepatoprotective efficacy. All biochemical markers and histological sections showed an effective significant change.

Because biochemical studies of blood samples from paracetamol-treated rats revealed a significant increase in serum enzyme activities, indicating liver injury caused by paracetamol, and blood samples from animals treated with the oral administration of ethanol extract revealed a significant reduction in serum enzymes alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP) to the acute hepatotoxic inducing inducing induc Using several marker enzymes and histological studies, they were able to show a considerable reduction in liver toxicity.

Conclusion: Based on these findings, Vitex negundo Linn. is efficient in protecting the liver against paracetamol-induced injury in rats at a level of 300 mg/kg/body weight. These findings imply that Vitex negundo Linn. leaves may help to protect hepatic cells.

Author(S) Details

P. L. Ladda
Appasaheb Birnale College of Pharmacy, Sangli (MS), India.

C. S. Magdum
Rajarambapu College of Pharmacy, Kasegaon (MS), India.

N. S. Naikwade
Appasaheb Birnale College of Pharmacy, Sangli (MS), India.

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