Pharmacotherapeutic Potential of Lawsonia inermis L.: Implications and Future Prospective

Both therapeutic and economic uses have been discovered for henna (Lawsonia inermis). Mehendi is made from the pigment lawsone, which is obtained from this plant. The henna plant contains a large number of secondary metabolites, which provide it medicinal qualities such as anticarcinogenic, antidiabetic, analgesic, immunostimulatory, and many others. This produces a big demand pressure that traditional farming can’t provide because of the low multiplication rate. The study’s main goals are to develop the plant from the lab to the field, analyse the secondary metabolite content of the plant using multiple assays, and see if in vitro plants have higher secondary metabolic accumulation than in vivo plants. HPLC analysis and comparative transcriptome analysis were performed, followed by KEGG analysis of the pathways, to further validate the findings. Methanol performed the best in the secondary metabolic assessments of all the solvents employed in the study. It was also intriguing to discover that in vitro plants accumulated more secondary metabolites than plants in the wild. The TRAPID platform revealed a substantial difference between the plant transcript sets, indicating that gene families and enzymes contributing to secondary metabolites being more abundant in vitro plants. For tissue culture produced plants, KEGG analysis revealed a vast number of pathways associated to secondary metabolites, such as terpenoids, phenols, and flavonoid production, which can be blamed for the plant’s diverse medicinal and commercial qualities. As a result, this research reveals that in vitro henna plants accumulate more secondary metabolites and have a higher multiplication rate than traditional farming. These expanded secondary metabolic pathways can improve the efficiency of in vitro plants for the commercial and pharmaceutical industries, allowing them to be propagated in a stable and controlled environment without exposing the plant to stress, preventing overexploitation.

Author(S) Details

Debapriya Das
Lady Brabourne College, India.

Sayak Ganguli
St. Xavier’s College (Autonomous), India.

Debleena Roy
Lady Brabourne College, India.

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