Assessing the Dynamics of Antioxidant Protection of Tear Fluid and Retrobulbar Blood Circulation in Diabetic Retinopathy

DR is a vascular consequence of diabetes that causes vision loss and blindness in persons of all ages. The goal of this study was to establish the biochemical parameters of the lacrimal fluid and the efficiency of tanakan endonasal electrophoresis in the treatment of non-proliferative diabetic retinopathy using colour Doppler imaging (CDI) in diabetic eyes (NPDR). Within ten days, 165 patients with NPDR were assigned to one of three groups: standard treatment (control group), daily Tanakan tablets (TT group), or daily endonasal electrophoresis of Tanakan (TE group). The Early Treatment Diabetic Retinopathy Study (ETDRS) severity scale was used to assess the phases of DR. At months 1, 3, and 6, the key end indicators were changes in DR severity (DRS), antioxidant activity of tears, and CDI. As DRS grows, NO levels fall gradually, according to this study. Peak systolic velocity (PSV) of the central retinal artery (CRA), central retinal vein (CRV), short posterior ciliary artery (SPCA) and DRS, and end-diastolic velocity (EDV) of the CRA and DRS were found to have moderate negative relationships. CDI values that show increased resistance or decreased flow can be used to predict a higher likelihood of severe DR, which is crucial for selecting patient care strategies.

Author(S) Details

Guzal Kangilbaeva
Department of Ophthalmology, Tashkent Medical Academy, Uzbekistan.

Fazilat Bakhritdinova
Department of Ophthalmology, Tashkent Medical Academy, Uzbekistan.

Feruza Urmanova
Department of Ophthalmology, Tashkent Medical Academy, Uzbekistan.

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