Safety Assessment of POLYSORB® ID a Fatty Acids-Diesters Isosorbide Used as a Plant-based Solutions for Plasticizers

Phthalate esters, principally di-ethylhexylphthalate (DEHP), are a group of compounds that are commonly employed as plasticizers for polyvinyl chloride in a variety of residential and industrial applications. These phthalate esters have a minimal toxicity in the environment. POLYSORB® ID 37, a combination of diesters derived via esterification of isosorbide with plant-based fatty acids, was created to solve these shortcomings. The toxicological and biodegradability investigations that were conducted to estimate both human and environmental risk assessments will be described in this article. POLYSORB® ID 37 was found to be non-toxic to mammalian life and rapidly biodegradable in all toxicological and biodegradability testing.

Author(S) Details

S. Simar-Menti`eres
Institut Pasteur de Lille-Laboratoire de Toxicologie G´en´etique, 1 Rue Du Pr. Calmette, Lille Cedex-59019, France.

F. Nesslany
Institut Pasteur de Lille-Laboratoire de Toxicologie G´en´etique, 1 Rue Du Pr. Calmette, Lille Cedex-59019, France.

M. L. Sola
ERBC, Chemin de Montifault, Baugy 18800, France.

S. Mortier
ERBC, Chemin de Montifault, Baugy 18800, France.

J. M. Raimbault
ERBC, Chemin de Montifault, Baugy 18800, France.

F. Gondelle
Ineris-Direction des Risques Chroniques, Pˆole VIVA, Unit´e EXES–Parc Technologique ALATA. BP 2, Verneuil-en Halatte-60550, France.

L. Chabot
Ineris-Direction des Risques Chroniques, Pˆole VIVA, Unit´e EXES–Parc Technologique ALATA. BP 2, Verneuil-en Halatte-60550, France.

P. Pandard
Ineris-Direction des Risques Chroniques, Pˆole VIVA, Unit´e EXES–Parc Technologique ALATA. BP 2, Verneuil-en Halatte-60550, France.

D. Wils
Roquette Frères, Toxicology & Safety Unit-Nutrition & Health R&D, 1, Rue de La Haute Loge, Lestrem-62136, France.

A. Chentouf
Roquette Frères, Toxicology & Safety Unit-Nutrition & Health R&D, 1, Rue de La Haute Loge, Lestrem-62136, France.

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