Determine the Protective Effect of Acorus calamus Rhizome in Paracetamol Exposure Induced Hepatotoxicity in Rats

Background: Because the liver is the primary organ for xenobiotic biotransformation, hepatic diseases or degeneration are still a serious health concern today. Even if there are several antioxidants and hepatoprotectives available, liver deterioration that has progressed beyond the ability to heal culminates in liver failure and death.

The goal of this study was to see if an aqueous and alcoholic extract of Acorus calamus rhizomes might protect rats against paracetamol-induced hepatotoxicity.

Hepatotoxicity was caused by taking paracetamol orally, and chemical parameters such glutathione peroxidase, glutathione reductase, glutathione, Catalase, lipid peroxidation, and histological alterations in the liver were compared to Silymarin, a typical hepatoprotective medication.

After paracetamol administration, treatment of rats with aqueous and alcoholic extracts of Acoruscalamus rhizome normalised the changed levels of the aforesaid parameters, which may be equivalent to Silymarin and Vit-E. Histopathological analysis of the liver tissue of control and treated animals verified the hepatoprotective action.

Conclusion: Based on the findings, it may be inferred that the rhizome of Acorus calamus protects rats against paracetamol-induced hepatotoxicity. The usage of Acoruscalamus may be indicated for lifestyle-related disorders such as hepatitis, as well as to promote overall health in animals, including humans. Prior to the therapeutic use of Acoruscalamus as an antioxidant, extensive investigations in target species should be conducted.


Author(s) Details:

G. Srividya,
Department of Veterinary Pharmacology and Toxicology, N. T. R College of Veterinary Science, Gannavaram, India.

K. Adilaxmamma,
Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science Tirupati, Andhrapradesh, India.

C. H. Srilatha,
Department of Veterinary Pathology, College of Veterinary Science Tirupati, Andhrapradesh, India.

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