Assessment of Chronic Inflammatory Demyelinating Polyneuropathy in Systemic Lupus Erythematosus

The central nervous system (CNS) is more commonly affected than the peripheral nervous system in Systemic Lupus Erythematosus (SLE). Neuropsychiatric or CNS signs are widespread, ranging from 24-54 percent, while peripheral nervous system involvement is less common, at roughly 5-27 percent. Chronic Inflammatory Demyelinating Polyradiculopathy (CIDP) is one of the three most common peripheral nerve system involvements in SLE patients, and it can be very disabling.

The goal of this study is to examine all SLE patients who have developed CIDP and report on their clinical symptoms, treatment, and progress, as well as a brief review of the literature on CIDP in SLE patients.

Methods: A retrospective review of all SLE patients diagnosed with CIDP between 2000 and 2015 who were followed up at our centre was conducted. We investigated their clinical presentation, investigations, treatment, response to therapy, and any neurological sequelae in their medical records.

There were 512 case notes analysed in total. These four patients, all between the ages of 26 and 46, presented with CIDP (3 females and 1 man). Three of the patients had transverse myelitis, while the fourth had acute motor and sensory axonal neuropathy. All of the patients were given high-dose corticosteroids, three of them were given cyclophosphamide, and the other was given mycophenolate mofetil. One patient had a complete recovery, two had persistent but improving numbness, and the third had lingering weakness. Two of our patients acquired CIDP shortly after being diagnosed with SLE, while the other two developed it much later in the course of their disease.

Conclusion: Involvement of the peripheral nerve system in SLE can have major disabling consequences. Early detection and treatment are critical for reducing neurological consequences.

Author(S) Details

Rozita Mohd
Nephrology Unit, Pusat Perubatan Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, 56000, Cheras Kuala, Lumpur, Malaysia.

Fatimah Zanirah Nordin
Nephrology Unit, Pusat Perubatan Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, 56000, Cheras Kuala, Lumpur, Malaysia.

Rizna Cader
Nephrology Unit, Pusat Perubatan Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, 56000, Cheras Kuala, Lumpur, Malaysia.

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