Visible Quantitative Methods for the Determination of Furosemide in Pure form and Pharmaceutical Formulations: A Recent Study

The goal of this research is to develop technological methods for determining furosemide in both its pure and pharmaceutical dose forms utilising spectral approaches.

This study was designed and carried out to assess Furosemide in pure and pharmaceutical dose forms using visible spectrophotometry.

This research was conducted from April to August 2021 at the Laboratory of Analytical Research, chemistry department, college of Science, University of Mosul, Mosul, Iraq.

The drug Lazix is made up of furosemide, which is used to treat heart disease and high blood pressure. To record the pH data, the researchers used a JASCO V – 630 double-beam computerised UV-Visible spectrophotometer with a 1 cm matched cell and a HANA pH metre.

Furosemide interacts with bromo-phenol blue, xylenol orange, and chromazorol S, according to research. The decreasing intensity of the resulting coloured complex was measured using bromo-phenol blue and xylenol orange, whereas the rising colour intensity was measured using method (C). The charge transfer reaction was used in all three approaches. The limits of Beer’s law were 0.8-32 g. mL-1 for method (A), 1-32 g. mL-1 for method (B), and 1-32 g. mL-1 for method (C), depending on the level of concentration, while the molar absorption coefficients were 1.4104, 2.1104, and 1.57104 l.mol-1.cm-1 for the first, second, and third methods, respectively. For these three approaches, Sandel’s significance was estimated as follows: 0.0157 g.cm-2 for the first method, 0.0236 g.cm-2 for the second method, and 0.0236 g.cm-2 for the third way. 0.0210 g.cm-2 was used in the third approach. With considerable success, the method has been used to identify furosemide in both its pure form and certain pharmaceutical forms.

The suggested methodologies were validated in terms of linearity, range, accuracy, precision, specificity, and robustness. Method (B) was determined to be the best method based on the best values of molar absorptivity, stability of the resulting complex, and method (A) was determined to be the best method based on the best values of molar absorptivity, stability of the resulting complex, and method (A) was determined to be the best method (B).

Author(s) Details:

Basima A. A. Saleem,
Department of Chemistry, College of Science, University of Mosul, Mosul, Iraq.

Enaam A. Hamdon,
Department of Chemistry, College of Science, University of Mosul, Mosul, Iraq.

Sahbaa Y. Majeed,
Department of Chemistry, College of Science, University of Mosul, Mosul, Iraq.

Please see the link here: https://stm.bookpi.org/PCSR-V1/article/view/6768

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