Cytotoxicity Measurements of CdSe and Ag Hybrid Nano Composites for In-vitro Bioimaging Applications

The antimicrobial properties of silver metal have long been known. The interaction of these metal nanoparticles with human cells suggests that they are harmless. We synthesised a hybrid nanocomposites of Ag with Cadmium Selenide (CdSe) Quantum Dots (QDs) for cytotoxicity testing in this study. These hybrid nanostructures can be exploited in medical detection and therapy due to the strong luminous characteristics of CdSe QDs. TEM was used to investigate the morphology of CdSe QDs and Ag composites with CdSe. The TEM picture demonstrated that Ag had developed a coating layer over the surface QDs. The cytotoxicity of CdSe-based QDs was assessed using the MTT test on the HEK293 cell line. The tests revealed that even at greater concentrations of 1000nM for 24 hours, QDs were less hazardous. When the toxicity levels of both samples were evaluated, it was discovered that the Ag with CdSe hybrid nanocomposites were less hazardous than CdSe QDs. Using an optical microscope, the morphology of the HEK293 cell line was continuously assessed. The composites of CdSe QDs with Ag can be employed in many biological imaging techniques as well as other medical diagnostics and therapies due to their lower toxicity.

Author(s) Details:

Neeraj Rathee,
Department of Material Science and Engineering, Indian Institute of Technology, Delhi, India.

Neena Jaggi,
Department of Physics, National Institute of Technology, Kurukshetra, India.

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