In Silico Prediction and 3D Model Analysis of Potential Epitope of Heat Shock Protein-70 (HSP70) Gallus gallus as Candidate Biomarkers for Poultry Meat Quality Tests

The major goal of this study was to look for possible heat shock protein-70 (HSP70) epitopes in chickens (Gallus gallus). The epitopes are crucial for developing a vaccination that will generate antibodies against HSP70, which can then be utilised as biomarkers to evaluate HSP70 expression. There is a link between HSP70, which indicates the presence of stresses, and meat quality, according to other studies. Physical, chemical, and biological stresses can reduce the quality of bird meat before, during, and after broiler slaughter. The discovery of a possible biomarker for HSP70 will be extremely useful in determining the quality of poultry meat. In this work, the HSP70 sequences of Gallus gallus were analysed in silico to look for possible epitopes as biomarkers. The approach employed was a bioinformatics-related software-based method. Two putative biomarker candidate peptides related to HSP70, AILMGDKSENVQD and ISWLDRNQMAEKEEYEHKQKELEK, were obtained from this investigation. These epitopes can also be used to create a three-dimensional model. More study is needed to demonstrate the efficacy of these two indicators in vivo.

Author(s) Details:

Sulaiman Ngongu Depamede,
Fakultas Peternakan Universitas Mataram, Jl. Majapahit 62 Mataram, NTB, 83125, Indonesia.

Budi Indarsih,
Fakultas Peternakan Universitas Mataram, Jl. Majapahit 62 Mataram, NTB, 83125, Indonesia.

I Ketut Gede Wiryawan,
Fakultas Peternakan Universitas Mataram, Jl. Majapahit 62 Mataram, NTB, 83125, Indonesia.

Muhamad Hasil Tamsil,
Fakultas Peternakan Universitas Mataram, Jl. Majapahit 62 Mataram, NTB, 83125, Indonesia.

. Maskur,
Fakultas Peternakan Universitas Mataram, Jl. Majapahit 62 Mataram, NTB, 83125, Indonesia.

Please see the link here: https://stm.bookpi.org/ECAFS-V5/article/view/6983

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