An Update on Etiology and Detection of Anti-sperm Antibodies in Males and Females

Both men and females produce anti-sperm antibodies (ASAs). Numerous pieces of evidence point to the possibility that at least some antibodies that attach to sperm antigens might result in sterility in humans and other mammals. Varicocele, cryptorchidism, certain viral and/or inflammatory illnesses of the male reproductive tract (MRT), and homosexuality have all been put up as potential risk factors for the development of ASAs in males. Up until recently, theories for the origin of sperm immunity in females have included cross-reactivity with microbial antigens, the potential participation of antibody idiotypes, and interferon gamma-mediated potentiation of antisperm immune response in women whose male partners had ASAs in their semen. Although a correlation between these risk factors and the development of ASAs has been shown in a number of studies, this connection is still debatable, indicating that our understanding of these disorders is incomplete. In order to determine the likely risk factors for the development and detection of ASAs, this chapter analyses the existing research.

Author(s) Details:

. Divya,
Department of Microbiology, Panjab University, Chandigarh, India.

Thomson Soni,
Department of Microbiology, Panjab University, Chandigarh, India.

Ishwerpreet Kaur Jawanda,
Department of Microbiology, Panjab University, Chandigarh, India.

Renu Jaiswal,
Department of Microbiology, Panjab University, Chandigarh, India.

Harkeerat Kaur,
Department of Microbiology, Panjab University, Chandigarh, India.

Vijay Prabha,
Department of Microbiology, Panjab University, Chandigarh, India.

Please see the link here: https://stm.bookpi.org/IMB-V6/article/view/7249

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