Capsid-Based Platform for Nano-Theranostic Reagent as Modularized Capsule: A Review

As a multipurpose platform for cancer targeting, imaging, and therapeutic applications, the hepatitis E virus nanoparticle (HEVNP), a modularized theranostics capsule made from the HEV virus-like particle (VLP), has been introduced. This can be achieved by encasing drugs, DNA/RNA, or even inorganic beads inside the capsule’s core and attaching various functional peptides and/or chemicals to the surface of the capsule utilising the flexible domain of HEVNPs. In terms of efficient cell penetration through active endocytosis, polyvalence (the capacity to attach multiple copies of active substances), and biocompatibility, VLPs offer benefits (the ability to withstand proteolytic degradation after delivery). In a number of medicinal applications, such as tumor-directed hyperthermia therapy, cancer imaging, and oral vaccinations, HEVNP’s tumour targeting and encapsulating characteristics might be exploited as a modular theranostics nano-capsule. gene therapies that target certain organs or tissues as well as non-targeting treatments.

Author(s) Details:

Chun-Chieh Chen,
Department of Molecular and Cellular Biology, University of California, USA.

Marie Stark,
Department of Molecular and Cellular Biology, University of California, USA.

Mo A. Baikoghli,
Department of Molecular and Cellular Biology, University of California, USA.

R. Holland Cheng,
Department of Molecular and Cellular Biology, University of California, USA.

Please see the link here: https://stm.bookpi.org/IMB-V6/article/view/7246

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