Antibiotic Sensitivity Pattern of Helicobacter pylori in Dyspeptic Patients in Kano, Nigeria

Half of the world’s population is thought to carry the common infection Helicobacter pylori (H. pylori). Eliminating H. pylori has a significant impact on how peptic ulcer disease and gastric cancer develop naturally, although antibiotic resistance is becoming recognised as a factor in certain patients’ failure to respond to H. pylori eradication therapy. It is crucial to assess H. pylori’s antibiotic sensitivity pattern in order to effectively eradicate the organism in the right patient group because many disorders linked to the pathogen are widely known. To get pertinent biodata, surveys were given out. Gastric biopsy samples were taken during endoscopy and cultivated using Columbia blood agar media (Oxoid Ltd, England) for the detection of H. pylori. The disc diffusion technique was used to evaluate the sensitivity profile of isolates. To ascertain the degree of eradication, pre- and post-treatment stool samples from each patient were collected for the H. pylori faecal antigen test. Levofloxacin and clarithromycin rendered H. pylori completely susceptible, but amoxicillin only rendered H. pylori 9.2 percent susceptible. It was discovered that all other tested antibiotics were completely resistant. Histology revealed an 81.7 percent prevalence of H. pylori. A considerable amoxicillin resistance rate was found in this investigation, whereas clarithromycin and levofloxacin showed good sensitivity (100 percent ). In Nigeria, we recommended using levofloxacin as part of a triple treatment regimen to eradicate H. pylori instead of amoxicillin.

Author(s) Details:

Ahmad K. Bello,
Department of Internal Medicine, Faculty of Medicine, Ahmadu Bello University / Ahmadu Bello University Teaching Hospital, Zaria, Nigeria.

Mohammad M. Borodo,
Department of Internal Medicine, Faculty of Health Sciences, Bayero University Kano, Aminu Kano Teaching Hospital, Kano, Nigeria.

Ahmad M. Yakasai,
Department of Infectious Diseases, Faculty of Clinical Sciences, Public Health and Diagnostic Institute, College of Medical Sciences, North-West University, Kano, Nigeria.

Abubakar D. Tukur,
Department of Microbiology, Faculty of Allied Health Science, Aminu Kano Teaching Hospital, Bayero University, Kano, Nigeria.

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Keywords: H. pylori antibiotic sensitivity, Kano-Nigeria, H. pylori Culture, histology, clarithromycin and levofloxacin sensitivity

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