Pyrrole Carboxamide Binol Conjugates: Chiral Receptors for Chemical Inversion of L-amino Acids to D- amino Acids

Four pyrrole carboxamide binol conjugates 1-4 have been employed as chirality conversion reagents (CCRs) to research the chemical inversion of L-amino acids to D-amino acids. This process creates a Schiff base type imine by using a resonance-assisted hydrogen bond, increasing the proton’s acidity (RAHB). The pendant groups’ heterocylic moiety and the additional hydrogen bonds that form between them and the amino acids aid in further stabilising the molecule. The conversion efficiencies of the pyrrole carboxamine-based receptors 1-4 were found to be comparable to those of the receptors previously reported.

Author(s) Details:

K. Velmurugan,
Fluorensic Materials Laboratory, Department of Applied Chemistry, Karunya Institute of Technology and Sciences (Deemed to be University), Karunya Nagar, Coimbatore-641 114, India.

Lijun Tang,
College of Chemistry and Chemical Engineering, Liaoning Key Laboratory for the Synthesis and Application of Functional Compounds, Bohai University, Jinzhou 121013, P. R. China.

J. Prabhu,
Fluorensic Materials Laboratory, Department of Applied Chemistry, Karunya Institute of Technology and Sciences (Deemed to be University), Karunya Nagar, Coimbatore-641 114, India.

R. Nandhakumar,
Fluorensic Materials Laboratory, Department of Applied Chemistry, Karunya Institute of Technology and Sciences (Deemed to be University), Karunya Nagar, Coimbatore-641 114, India.

Please see the link here: https://stm.bookpi.org/PCSR-V5/article/view/8479

Keywords: Pyrrole carboxamide binol conjugates, chiral recognition, amino acids, chiral inversion, 1H-NMR

Previous post Phenolic Compounds from Rumex L: Their Extraction, Structural Identification and Biological Activity
Next post Investigation of Solution Behaviour of Potassium Halides in Aqueous Solution of L- Proline at Different Temperatures: A Physicochemical Approach