A Comprehensive Study on Anticancer Activity of Tridax procumbens Leaf Extracts on A549 and Hep G2 Cell Lines

Cancer is a affliction that is harshly accomplishing the global human society. There is forever a continual demand for new analyses to treat and bar this severe disease. Scientific and research interest is illustration allure consideration towards commonly derivative compounds, as they are thought-out to have less poisonous side effects distinguished to current situations to a degree a destructive agent, fallout etc. Medicinal plant Tridax procumbens produces easily occurring subordinate metabolites that is being examined for the anticancer actions against A549 (human body part tumor container line), Hep G2 (human liver carcinoma container line) superior to the growth of new dispassionate drug.MTT and trypan sad dye expulsion assays were used to assess the anticancer endeavor of T.procumbens intoxicating, acetone, and liquid leaf extracts on picked human malignant container lines. The MTT assay relies on the talent of practicable containers’ mitochondrial enzymes to convert the yellow dissolved seasoning MTT to the violet sky insoluble formazan hurry, that is therefore distinguished spectrophotometrically at 570 nm. The Trypan sad assay depends cell staining. Cells are before looked under a microscope utilizing a hemocytometer, and non-practicable containers are tainted sad while viable containers wait spotless.The liquid leaf extract of T. procumbens has not proved some anticancer activity. However, acetone and intoxicating leaf extracts of T. procumbens has proved forceful anticancer exercise on A549 (human pleura tumor container line), Hep G2 (human liver carcinoma container line).T. procumbens examined for anticancer potential by MTT assay and trypan sky expulsion assay. The acetone and intoxicating leaf extracts of T. procumbens have proved potent anticancer venture on picked human container lines.

Author(s) Details:

Pittu Vishnu Priya,
Department of Pharmaceutical Biotechnology, Joginpally B.R Pharmacy College, Yenkapally (V), Moinabad (M), Telangana, Hyderabad-500 076, India.

A. V. S. S. S. Gupta,
Department of Pharmacology, Joginpally B.R Pharmacy College, Yenkapally (V), Moinabad (M), Telangana, Hyderabad-500 076, India.

A. Srinivasa Rao,
Department of Pharmacology, Bhaskar Pharmacy College, Yenkapally (V), Moinabad (M), Telangana, Hyderabad-500 076, India.

Please see the link here: https://stm.bookpi.org/CAPR-V10/article/view/8828

Keywords: Anticancer activity, Tridax procumbens, 3-(4, 5-dimethyl-thiazole-2-yl)-2,5-diphenyl tetrazolium bromide assay, trypan blue exclusion assay, A549, Hep G2

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