Technology Innovations in Colon Targeted Drug Delivery Systems

Drug point or direct at a goal to colon has numerous advantages into the framework of reduction of reactions, lesser chance of dose disposal, lesser drug degradations and successful administration of local diseases viz., ulcerative colitis, Crohn’s affliction, irritable bowel condition, chronic pancreatitis and colon cancer as per reports. These are likely only if those delivery systems are intelligent to target drugs straightforwardly into the colon specific region favorably. Drug targeting to colonic region by way of oral route had happened utilized for newer science-based proteins and peptide types drugs. These colon specific drug transmittal systems are more advantageous in many facets in comparison to possible conventional types marketed portion of drug or other consumable forms. These colon specific systems are promoting for obtaining local, local and/or systemic absorptions for the purpose of possible administration of local colon diseases. Colon targeting bypasses those sour and enzymatic assaults of drugs in upper gastrointestinal lot during spoken drug administration. Fewer formulation approaches and mechanisms had been grown by our researchers for acquiring maximum possible benefits of desired pharmacological conduct in this regard. This present article is emphasize for colonic drug targeting parameters containing novel approaches, physico-chemical countenance, newer advanced transfer systems, formulation approaches, multiparticulate systems, characterizations of childbirth systems, etc.

Author(s) Details:

Meenakshi Jaiswal,
Department of Pharmacy, Guru Ghasidas Vishwavidyalaya (A Central University under the Act 2009), Bilaspur (C.G.)- 495009, Chhattisgarh, India.

S. K. Lanjhiyana,
Department of Pharmacy, Guru Ghasidas Vishwavidyalaya (A Central University under the Act 2009), Bilaspur (C.G.)- 495009, Chhattisgarh, India.

Please see the link here: https://stm.bookpi.org/TICTDDS/article/view/8807

Keywords: Drug targeting, gastrointestinal tracts, targeting approaches, pH gradients, colonic microfloras, bacterial enzymes, colon drug delivery, formulation development, colon diseases, In vitro – In vivo methods

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