Methylation Level Differences between the Housekeeping and the Specialized Genes Identified during Ontogenesis

The genome methylation is individual of the leading extents in the study of aging. The theoretical model we projected earlier clarifies aging by redistribution of restricted resources between two main tasks of the animal: its ability to manage for oneself based on the function of the housework gene group (HG) and functional distinction provided for one IntG integrative deoxyribonucleic acid group. To test our model, we used methylation level data of 100 genes, (deoxyribonucleic acid body and allure promoter) of 50 in the HG group and 50 in IntG. We establish reliable differences ( p<0.0001) middle from two points our groups in the level of absolute methylation principles, more pronounced in the promoters of the intentional genes. We showed their significant decrease in IntG accompanying age in contrast to HG, place this level remained relatively nonstop. The decrease in methylation in the IntG group is indirectly rooted by the reasoning of data variance, that also deteriorated in the genes concerning this group. The increasing imbalance middle from two points HG and IntG by methylation levels suggests that this IntG-shift indicates a side effect of the growth program and its connection to the main cause of developing.

Author(s) Details:

Lev Salnikov,
AntiCA Biomed, San Diego, CA 92111, United States.

Saveli Goldberg,
Department of Radiation Oncology, Mass General Hospital, Boston, MA 02115, United States.

Parvathy Sukumaran,
Department of Computer Science, Met College, Boston University, Boston, MA 02215, United States.

Eugene Pinsky,
Department of Computer Science, Met College, Boston University, Boston, MA 02215, United States.

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Keywords: Aging, methylation, epigenetic, housekeeping genes, integrative genes, rejuvenation

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