Flavonoids from Vietnamese Dalbergia oliveri and their Anti-inflammatory Activity

The ethyl acetate dissolved part of Vietnamese Dalbergia oliveri was bear hardship column chromatography utilizing silica coagulate and Sephadex LH-20 to separate chemical compound in consideration of evaluate the phytochemical parts and their stop of NO production. From the heartwood of D. oliveri, nine subordinate metabolites (1–9) were successfully gleaned. The synthetic forms of these compounds were labeled as daidzein (1), formononetin (2), 3,7-dihydroxy-4¢-methoxyflavone (3), liquiritigenin (4), 3¢-methoxydaidzein (5), dalbergin (6), butin (7), sativanone (8), and isoliquiritigenin (9). The synthetic structures of unique compounds were recognized by basic attractive resonance dossier and corresponding accompanying earlier reported brochure. The compounds 1, 3, and 5–8 were private from D. oliveri for the first occasion. The antagonistic-swelling effects of the private compounds on the lipopolysaccharide (LPS)-inferred NO result in RAW 264.7 containers were measured utilizing the Griess backlash. Compounds 7 and 9 had the most powerful inhibitory venture, with IC50 principles of 7.6 and 11.2 μM, individually, and were attended by 3-6, that had IC50 principles ranging from 19.6 to 28.7 μM. The judgments submitted that the NO-preventing characteristics of D. oliveri and its unaffected compounds concede possibility have antagonistic-instigative benefits.

Author(s) Details:

Nguyen Thi Ai Nhung,
Department of Chemistry, University of Sciences, Hue University, Hue City-530000, Vietnam.

Truong-Nhan Ngu,
Department of Natural Sciences and Technology, Tay Nguyen University, 567 Le Duan, Buon Ma Thuot, Dak Lak-630000, Vietnam.

Phi-Hung Nguyen,
Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Caugiay, Hanoi-122100, Vietnam.

Manh-Hung Tran,
School of Medicine and Pharmacy, The University of Danang, Hoa Quy, Ngu Hanh Son, Da Nang City-550000, Vietnam.

Phan Tu Quy,
Department of Natural Sciences and Technology, Tay Nguyen University, 567 Le Duan, Buon Ma Thuot, Dak Lak-630000, Vietnam.

Dao-Cuong To,
Phenikaa University Nano Institute (PHENA), Phenikaa University, Yen Nghia, Ha Dong district, Hanoi-12116, Vietnam.
Please see the link here: https://stm.bookpi.org/CPAFS-V1/article/view/8916

Keywords: Dalbergia oliveri, flavonoid, inflammation, NO production, cytotoxic, RAW264.7 cells