2-Amino-N-(Substituted Alkyl) Benzoxazole-5- Carboxamide Derivatives as Antiinflammatory and Antioxidant Drugs

The objective of whole follow integrate, writing and Pharmacological doom of 2-Amino-N-(substituted alkyl) benzoxazole-5- carboxamides for opposing-inflaming and antioxidant endeavors compensate from 4-carbomethoxynitrophenol. Evaluation of the compounds disclosed Vc(R=ethyl), Ve(R=propyl) and Vg (R=diisopropyl) V g (R=propyl) as greatest active individual. When outstanding to the standard ascorbic acid, compound Vf (R=isopropyl) presented a densely more generous allocation of free radical scavenging project accompanying an IC 50 of 4.65. Vf is deduced as a drug that has two together opposing-infuriating and antioxidant properties.

Author(s) Details:

Arunadevi Parlapalli,
Department of Pharmaceutical Chemistry, University College of Pharmaceutical Sciences, Kakatiya University, Warangal 506009, India.

Kishore,
Department of Pharmaceutical Chemistry, University College of Pharmaceutical Sciences, Kakatiya University, Warangal 506009, India

Manasa Cidda,
Department of Pharmaceutical Chemistry, University College of Pharmaceutical Sciences, Kakatiya University, Warangal 506009, India.

Sarangapani Manda,
Department of Pharmaceutical Chemistry, University College of Pharmaceutical Sciences, Kakatiya University, Warangal 506009, India.

Please see the link here: https://stm.bookpi.org/COPS-V2/article/view/9171

Keywords: Benzoxazole, synthesis, anti-inflammatory, antioxidant