Bioinformatics Approach Reveals the Insecticidal Potential of Geosmin by its Binding Efficacy with the Odorant Binding Protein of Various Insects

Geosmin is an unsophisticated and muddy odorant compound caused by some microorganisms present in the moist soil. It is evident that it has excellent influence on insects. This study aims to resolve the effectiveness of geosmin binding to the odorant binding protein and allure insecticidal activity against miscellaneous insects. The discovery of smell in insects to a degree moth, aphids is aided for one olfactory receptors that are localized in the receiver. The olfactory receptors occupy odorant binding protein. The inactive form concerning this protein turns active when a synthetic or odorant compound binds to it. The active form of the protein triggers a signal transduction cascade that results in neuronal arousing and brain-concentrated perception of the odorant, that in turn brings about the appropriate behavioral answer of the insects. As a result of this celebration, the analysis of interaction betwixt odorant compound geosmin and insects is finished. Technologically, by the operation of the odorant compound Geosmin, the influence of insects on the crops maybe reduced. Ultimately the habit of insecticides in the agricultural field maybe reduced. Hence, in the present study various olfactory receptor proteins of miscellaneous insects composed from NCBI database and ethnic analysis was accomplished using MEGA11 operating system. The protein structure was modeled utilizing SWISS MODEL SERVER and the molecular interplay was analyzed utilizing AUTODOCK software. The results displayed that the among the picked insect variety, Geosmin has more influence on Galeruca Daurica and has lowest binding energy of about -8.73kcal/Mol.

Author(s) Details:

T. Kirthika,
Department of Biotechnology, Prathyusha Engineering College, Aranvoyal Kuppam, Tiruvallur, Chennai, Tamil Nadu, India.

S. Nandhini,
Department of Biotechnology, Prathyusha Engineering College, Aranvoyal Kuppam, Tiruvallur, Chennai, Tamil Nadu, India.

R. Gayathri,
Department of Biotechnology, Prathyusha Engineering College, Aranvoyal Kuppam, Tiruvallur, Chennai, Tamil Nadu, India.

A. Praveena,
Department of Biotechnology, Prathyusha Engineering College, Aranvoyal Kuppam, Tiruvallur, Chennai, Tamil Nadu, India.

Please see the link here: https://stm.bookpi.org/CERB-V3/article/view/9194

Keywords: Geosmin, olfactory receptors, olfactory receptors, NCBI, blast, SWISS MODEL, AUTODOCK, MEGA11