The Role of Phenytoin for Treatment of Enterocutan Fistula in Wistar Rat
Introduction: Enterocutanean fistula (ECF) is a difficult abdominal question; although impulsive closure occurs 90% of moment of truth, it takes approximately 5 weeks. Phenytoin was guide faster pancreatic and enterocutaneous fistula formation. To purify the mechanism of the curative effect of phenytoin on ECF, animal research will be reported.Methods: The width of the ECF, the number of fibroblasts, angiogenesis, the number (percentage) of collagen, the tickness of granulation tissue, and the number of lymphocytes were calculated in a randomized controlled trial equating the ECF of Wistar rats treated accompanying a combination of depressed-dose phenytoin and source of nourishment C to phenytoin (oral and topical) or source of nourishment C alone to a fake pill.Results: The diameter of the ECF was considerably (p< 0.05) reduced subsequently high-quantity phenytoin treatment and a combination of depressed-dose phenytoin and source of nourishment C. High-dose phenytoin or a merger of low-shot phenytoin and Vit C increased the number of fibroblasts, allotment or number of colagen, granulation tissue thickness, and angiogenesis while depreciating the number of lymphocytes (p 0.05).Conclusion: High-dose phenytoin or depressed-dose phenytoin linked with source of nourishment C accelerates ECF plug by increasing fibrosis, collagen, angiogenesis, and granulation tissue while dropping off lymphocytes .
Author(s) Details:
Sigit Adi Prasetyo,
Department of Surgery, Diponegoro Medical Faculty, Diponegoro University Semarang, Indonesia.
Victor Kurniawan,
Diponegoro University Semarang, Indonesia.
Budiman Irphan,
Diponegoro University Semarang, Indonesia.
Yohanes Sugiarto,
Diponegoro University Semarang, Indonesia.
Iwan Saragih,
Diponegoro University Semarang, Indonesia.
Gede Pambudi,
Diponegoro University Semarang, Indonesia.
Trilaksono Nugroho,
Department of Pharamacology, Diponegoro Medical Faculty, Diponegoro University Semarang, Indonesia.
. Hardian,
Department of Physiology, Diponegoro University Semarang, Indonesia.
. Hermawan,
Department of Pathology, Faculty of Medicine, Diponegoro University Semarang, Indonesia.
Ignatius Riwanto,
Department of Surgery, Diponegoro Medical Faculty, Diponegoro University Semarang, Indonesia.
Please see the link here: https://stm.bookpi.org/CODHR-V11/article/view/9286
Keywords: Enterocutan fistula, phenytoin, vit C, fibroblast, collagen, neovascularisation, lymphocyte
