An Introduction to Base Editing and Prime Editing: Principles and their Importance

The present study present readers to the concepts and standard of “Base editing” and “Prime rewriting” – two very important methodologies that almost revolutionized the field of Genome Editing over ancient times few years. Prime editing shows greater or similar effectiveness and fewer byproducts than homology-supervised repair, has complementary substances and weaknesses compared to base rewriting, and induces much lower off-target refining than Cas9 nuclease at known Cas9 off-target sites. Prime refining substantially expands the outlook and capabilities of genome editing, and in standard could correct until 89% of known genetic variations associated with human ailments.

Author(s) Details:

Alex Sobko,
Department of Molecular Cell Biology, Weizmann Institute of Science (WIS), Rehovot, 76100, Israel. #PhD. 8762728, Ofakim, Israel.

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Keywords: Crispr, genome editing, base editing, prime editing

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