An Introduction to Base Editing and Prime Editing: Principles and their Importance
The present study present readers to the concepts and standard of “Base editing” and “Prime rewriting” – two very important methodologies that almost revolutionized the field of Genome Editing over ancient times few years. Prime editing shows greater or similar effectiveness and fewer byproducts than homology-supervised repair, has complementary substances and weaknesses compared to base rewriting, and induces much lower off-target refining than Cas9 nuclease at known Cas9 off-target sites. Prime refining substantially expands the outlook and capabilities of genome editing, and in standard could correct until 89% of known genetic variations associated with human ailments.
Author(s) Details:
Alex Sobko,
Department of Molecular Cell Biology, Weizmann Institute of Science (WIS), Rehovot, 76100, Israel. #PhD. 8762728, Ofakim, Israel.
Please see the link here: https://stm.bookpi.org/RDMMS-V5/article/view/9967
Keywords: Crispr, genome editing, base editing, prime editing
