Increased expression and activity of matrix metalloproteinase-2 (MMP-2) has been correlated with an increase in invasive potential and a worse prognosis in many cancers including melanomas. The antitumorigenic potential of all-trans retinoic…
Category: Biotechnology
Endocrine Disrupting Compounds (EDCs): The Risks for Aquatic Fauna
Many natural and synthetic compounds like fungicides, plasticizers, phytoestrogens and xenoestrogens released into the aquatic environment from sewage discharges, agricultural runoffs and industrial effluents can lead to endocrine disruption in exposed species…
Experimental Investigation on Physico-chemical Properties of Bio-ethanol/Gasoline Blends and the Qualitative Effect of Different Blends on Gasoline Quality and Engine Performance
Physico-chemical and operational properties of various gasoline bio-ethanol blends were evaluated. Bio-ethanol was obtained through distillation from maize (Zea mays), sugar cane (Saccharum L), raffia (Raffia vinefera) wine, and palm wine and…
Indian Tinospora Species: As Antibacterial Agents and Phytochemical Evaluation
Tinospora cordifolia (Family: Minispermaceae), mainly found at tropical regions of India. It is widely used as a medicine in the Folk and Ayurvedic Systems. It possesses general adatogenic, rejuvenating and immunomodulatory activity…
Agricultural Production and Climate Change: The Scope for Innovation in the Post-COVID 19 Scenario
The adverse effects of climatic changes on agriculture have always been an issue of global concern. In the post COVID-19 crisis scenario, such issue related to food security will gain more importance,…
Antagonistic Efficacy of Lactic Acid Bacteria against the Human and Fish-borne Microbiota of Fresh Indian Mackerel Fish Chunks
Various strains of lactic acid bacteria (LAB) namely Lactobacillus acidophilus NCIM 2287, Lactobacillus plantarum NCIM 2085, Lactobacillus helveticus NCIM 2126 and Lactococcus lactis NCIM 2114 were procured from the National Chemical Laboratory…
Acute and Sub-chronic Toxicity Study of the Extract and Powder of Operculina macrocarpa (L.) Urb. in Mice: Recent Perspectives
The aim of the study was to evaluate the experimental acute and sub-chronic toxicities of Operculina macrocarpa with plant extract and powder, respectively, in male and female mice. Phytochemical prospection was performed…
Advanced Research on Malignant Hyperthermia: A Runaway Thermogenic Futile Cycle at the Sodium Channel Level
Malignant Hyperthermia (“MH”)—the rapid onset of extremely high fever with muscle rigidity—is caused by a runaway heat production futile cycle mediated via the sodium channels at the myoneural receptor sites. MH is…
The Biology, Engineering and Applications of CRISPR/Cas9 System
Microbes use diverse defense strategies that allow them to withstand exposure to a variety of genome invaders such as bacteriophages and plasmids. One such defense strategy is the use of RNA guided…
RNA Polymerase: The Master Executor
RNA polymerases belong to a selected group of evolutionarily conserved proteins. Their role emerged with the coming of DNA molecules having more stability than the RNA molecules, which formed the RNA world…