Investigation on the Anti-Ulcerogenic Activity of Aqueous Extract of Unripe Fruit of Musa sapientum Linn in Combination with Vitamin C on Ulcer Induced Models in Experimental Rats

The aim of this study was to see how an aqueous extract of Musa sapientum Linn’s unripe fruit combined with Vitamin C affected aspirin and ethanol-induced ulcer models in Wistar rats. It’s a tropical plant whose fruit is commonly eaten as a healthy food all over the world.

Anti-ulcer research was conducted.

Between February and April 2016, I studied at the Department of Pharmacology and Therapeutics at Delta State University in Abraka, Delta State, Nigeria.

Methodology: For each model, 45 rats were divided into 9 groups of five. The animals were given doses of 250 mg/kg, 500 mg/kg, and 1000 mg/kg of Musa sapientum (MS) alone and in combination with Vitamin C 100 mg/kg (1:1), while another group received Vitamin C 100 mg/kg and the control group received distilled water. A separate group received omeprazole 20 mg/kg. The animals’ stomachs were cut for inspection after they were sacrificed.

Results: In both models, the aqueous extract of unripe Musa sapientum Linn fruit showed a substantial (P0.05) reduction in ulcers, which was boosted by the addition of Vitamin C.

Conclusion: Vitamin C potentiates the anti-ulcerogenic activity of unripe Musa sapientum fruits in rats, according to this report.

Author (s) Details

Emuesiri Goodies Moke
Department of Pharmacology and Therapeutics, Delta State University, Abraka, Delta State, Nigeria.

Lisa Iziegbe Omorodion
Department of Pharmacology and Therapeutics, Delta State University, Abraka, Delta State, Nigeria.

Hitler Augustine Akpoguma
Department of Pharmacology and Therapeutics, Delta State University, Abraka, Delta State, Nigeria.

Precious Imere
Department of Pharmacology and Therapeutics, Delta State University, Abraka, Delta State, Nigeria.

Ejiroghene Ahante
Department of Pharmacology and Toxicology, University of Nigeria, Nsukka, Enugu State, Nigeria.

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