Microneedle (MN) assisted transdermal delivery is a new technology that enables drugs to pass through the skin’s stratum corneum barrier and increase their permeation. Due to hepatic first pass metabolism, antimigraine drugs Zolmitriptan (ZT) and Rizatriptan (RT) have low and variable bioavailability when administered as currently available formulations. To efficiently deliver these molecules, transdermal delivery with MN application as a permeation enhancement strategy was tried. The poke and patch system was used to achieve this. MN application resulted in a substantial increase in transdermal permeation of both medications. It was also discovered that design parameters such as MN length, needle density, and other variables play a significant role in this enhancement. Overall, MN application, particularly through the poke and patch technique, appears to be a very promising technology that could pave the way for transdermal drug delivery to become the primary route in the future.
Author (s) Details
Dr. Buchi N. Nalluri
Department of Pharmaceutics and Biotechnology, KVSR Siddhartha College of Pharmaceutical Sciences, Vijayawada-520010, Andhra Pradesh, India.
Chandra Teja Uppuluri
Department of Pharmacy, BITS-Pilani Hyderabad Campus, Jawaharnagar, Shameerpet (M), Hyderabad 500078, Telangana, India.
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