News Release on Coinfection Research: September-2018

Can a viral co-infection impair immunity against Plasmodium and turn malaria lethal?

It is well-known that infections with sure viruses will weaken the immune reaction to a different infective agent. a brand new study reports provocative findings in mice that infection with the mouse equivalent of herpes will flip infections with sure parasites that cause protozoal infection in mice (which are usually quickly suppressed by the immune system) into a deadly illness. [1]

Intranasal coinfection model allows for assessment of protein vaccines against nontypeable Haemophilus influenzae in mice

Purpose. Nontypeable Haemophilus influenzae (NTHi) may be a commensal within the human cavum and also the explanation for respiratory illness, meningitis, sinusitis, acute exacerbations of chronic preventative pulmonic sickness and acute otitis (AOM). AOM is that the commonest ill that antibiotics area unit prescribed within u.  s… With the emergence of recent strains of antibiotic-resistant microorganism, finding a good and broad coverage immunizing agent to guard against AOM-causing pathogens has become a priority. Mouse models area unit an economical and economical thanks to facilitating confirm immunizing agent effectuality. Here, we have a tendency to describe Associate in Nursing NTHi AOM model in C57BL/6J mice, that conjointly utilizes a mouse-adapted H1N1 respiratory disorder virus to mimic human coinfection. [2]

The Burden of the Coinfection of HIV and TB in the Presence of Multi-drug Resistant Strains

We introduce a fractional-order model for the coinfection of the immunological disorder virus and TB, in the presence of drug-resistant TB strains and treatment for each disease. we have a tendency to calculate the copy variety of the model. Numerical simulations show the various dynamics of the model for variation of relevant parameters. [3]

Leprosy and ganglionar tuberculosis coinfection in an adult

The case report of a thirty-four-year-old patient is delineated  WHO came to the medical specialty Service thanks to disseminated pruritic erythroderma stains. once three months with specific treatment he began to gift evening low fevers and painful cervical adenopathies, reason why a bacilloscopy was indicated in each elbows and ear pavilions, however, the mycobacteria wasn’t found; besides aspiration diagnostic test with fine needle of a cervical neural structure was conjointly administrated, that result discovered a ganglionar TB. Finally a infectious disease and TB ganglionar coinfection was diagnosed, 2 diseases rising thanks to the eubacteria, that beingness is strange. [4]

The Effect of Co-infection of HIV and Hepatotropic Viruses on Selected Biochemical and Haematological Markers of Patients in Northeastern Nigeria

Background: As deaths caused by HIV declines with the utilization of medicine, disease related to co-infection of HIV with hepatotropic viruses has become AN increasing reason behind morbidity and mortality.

Aim: To assess the result of HIV-mono and co-infections with hepatotropic viruses on hematological and organic chemistry markers of the patients.

Methodology: 109 HIV patients from tertiary health facilities in northeastern Nigeria were ab initio screened with Immuno activity kit for HIV protein and confirmed by western blot prospectively and consecutively. However, serum hepatitis virus surface substance (HBsAg) and viral hepatitis virus (HCV) protein were detected on the HIV positive patients by assay. Blood donors served as management. The study was conducted between Gregorian calendar month and Gregorian calendar month 2012. [5]

Reference

[1] Can a viral co-infection impair immunity against Plasmodium and turn malaria lethal?

Date: May 21, 2015, Source: PLOS (web link)

[2] Intranasal coinfection model allows for assessment of protein vaccines against nontypeable Haemophilus influenzae in mice

Michel LV, Kaur R, Zavorin M, Pryharski K, Khan MN, LaClair C, O’Neil M, Xu Q, Pichichero ME. Intranasal coinfection model allows for assessment of protein vaccines against nontypeable Haemophilus influenzae in mice. Journal of medical microbiology. 2018 Aug 23. (web link)

[3] The Burden of the Coinfection of HIV and TB in the Presence of Multi-drug Resistant Strains

Carvalho A, Pinto CM. The Burden of the Coinfection of HIV and TB in the Presence of Multi-drug Resistant Strains. InDynamical Systems Theory and Applications 2017 Dec 11 (pp. 87-97). Springer, Cham. (web link)

[4] Leprosy and ganglionar tuberculosis coinfection in an adult

Tablada Robinet ME, Marrero Rodríguez H, López Pupo N. Leprosy and ganglionar tuberculosis coinfection in an adult. MediSan. 2018;22(07):559-66. (web link)

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