News Update on Autoimmune Disease Research: May – 2019

Type I Interferons in Autoimmune Disease

Type I interferons, that frame the primary protein family to be delineate and are the essential mediators of antivirus host defense, have emerged as central parts within the immunology of general response diseases, with general autoimmune disorder because the example. Lessons from investigation of antiviral agent regulation following infection are often applied to lupus, with the conclusion that sustained production of sort I antiviral agent shifts nearly all elements of the system toward pathologic functions that end in tissue injury and malady. we tend to review recent information, in the main from studies of patients with general autoimmune disorder, that offer new insights into the mechanisms of induction and therefore the immunological consequences of chronic activation of the sort I antiviral agent pathway. Current ideas implicate endogenous nucleic acids, driving each cytosolic sensors and endosomal Toll-like receptors, in antiviral agent pathway activation and recommend targets for development of novel medicine that will restore the system to health. [1]

Use of levocetirizine and montelukast in the treatment of autoimmune disorders

The embodiments represented herein embrace ways and formulations for treating response disorders. The ways and formulations embrace, however don’t seem to be restricted to, ways and formulations for delivering effective concentrations of levocetirizine and montelukast to a patient in would like. The ways and formulations will comprise typical and/or modified-release parts, providing for drug delivery to the patient. [2]

The microbiome in autoimmune diseases

The microbiome is described by microorganisms that sleep in a dependent method with the class. Microorganisms have the power to influence completely different physiological aspects like the system, metabolism and behavior. In recent years, many studies have highlighted the role of the microbiome within the pathological process of response diseases. Notably, in general autoimmune disorder associate degree alteration of the microorganism (lower Firmicutes/Bacteroidetes ratio) has been delineated . Conversely, changes to the gut commensal and disease are projected as vital factors within the pathological process of arthritis. At the identical time, different response diseases (i.e. general induration, Sjögren’s syndrome and anti‐phospholipid syndrome) conjointly share modifications of the microbiome within the enteral tract and oral flora. Herein, we have a tendency to describe the role of the microbiome within the maintenance physiological state of the system then the alterations of the microorganisms that occur in general response diseases. Finally, we’ll contemplate the utilization of probiotics and dirty  transplantation as novel therapeutic targets. [3]

Androgen deprivation therapy for prostate cancer and the risk of autoimmune diseases

Background

Androgen deprivation medical care (ADT) has been a mainstay of treatment for advanced prostatic adenocarcinoma (PCa), however restricted studies are performed to research the association between ADT and reaction diseases.

Methods

We conducted a population-based nationwide cohort study of seventeen,168 patients new diagnosed with PCa between 1996 and 2013 victimization the National insurance analysis info (NHIRD) of Taiwan. Cox proportional hazards models with 1:1 propensity score-matched analysis were accustomed investigate the association between ADT use and also the risk of reaction diseases. The reaction maladys enclosed Graves’ disease, Crohn’s malady, psoriasis, general LE, autoimmune disorder, autoimmune disease, infectious polyneuritis, Sjogren’s syndrome, myasthenia, anaemia, hereditary anemia, periarteritis nodosa, upset, uveitis, polymyalgia rheumatica, myositis, Hashimoto’s rubor, hypersensitivity rubor, Behcet’s malady, myositis, alopecia, Wegener’s granulomatosis, inflammatory bowel disease, reaction anemia, pemphigus, disseminated multiple sclerosis, general pathology, Goodpasture syndrome, big cell rubor, thromboangitis obliterans, rubor obliterans, and disease. The length of ADT use as a time-dependent variable was conjointly examined for its association with reaction diseases. we have a tendency to conjointly performed six secondary analyses.

Results

Of the 17,168 hand-picked PCa patients, 14,444 patients met all the inclusion and exclusion criteria. once propensity score matching, 5590 ADT users and 5590 non-ADT users were enclosed within the study cohort. A propensity score-matched analysis (adjusted hazard quantitative relation (aHR), 0.619, ninety five confidence interval (CI), 0.51–0.75, P [4]

Utility of Placental Umbilical Cord Blood in Autoimmune and Degenerative Disorders

Background: fetal membrane blood is whole human blood (60 to eighty ml) that is still within the placenta and umbilical cord once childbirth; usually thought-about as a medical waste. it’s a fashionable supply of stem cells, protein, cytokines, etc., and, will be collected, keep and utilised within the treatment of incurable diseases.

Aims and Objects: The aim of the current study is to determine the very fact that placental fetal membrane blood may be a safe different to adult blood and to assess its utility in chronic and autoimmune disorder together with its haematological parameters.

Materials and Methods: it’s a prospective 2 year study (From Sep 2016 to August 2018) of 250 fetal membrane blood transfusions in reaction and chronic disorders at Gajra Raja Medical faculty, Gwalior, India. Follow of patients was wrapped to three months and knowledge was collected and analyzed statistically by distribution and proportion proportion.

Results: a complete of 250 units meeting the inclusion and exclusion criteria were transfused to ninety nine preregistered patients; skin problem sixty one (159 transfusions), hypochromic anaemia fifteen (30), rubor Pigmentosa nine (23), Geriatric Disorders nine (24), aplastic anaemia four (9) and High nearsightedness one (5). Out of 250 transfusions, in one case (0.4%) adverse event was according. Outcome of transfusion reveals; In skin problem –regimentation in affected space, Thalassemia-reduction in frequency of transfusions, rubor Pigmentosa- improvement in vision space, Geriatric patients- sense of well being, Aplastic anemia- prolonged survival and High Myopia-improvement in vision space.

Conclusion: fetal membrane blood is safe and real different of adult blood. it’s effective in chronic and reaction diseases. It shouldn’t be discarded as medical waste and utilised judiciously within the human well being.[5]

Reference

[1] Crow, M.K., Olferiev, M. and Kirou, K.A., 2019. Type I interferons in autoimmune disease. Annual Review of Pathology: Mechanisms of Disease14, pp.369-393. (Web Link)

[2] May, B.C., Irr Inc, 2019. Use of levocetirizine and montelukast in the treatment of autoimmune disorders. U.S. Patent Application 10/201,537. (Web Link)

[3] De Luca, F. and Shoenfeld, Y., 2019. The microbiome in autoimmune diseases. Clinical & Experimental Immunology195(1), pp.74-85. (Web Link)

[4] Androgen deprivation therapy for prostate cancer and the risk of autoimmune diseases

Jui-Ming Liu,Cheng-Ping Yu,Heng-Chang Chuang,Chun-Te Wu &Ren-Jun Hsu 

Prostate Cancer and Prostatic Diseases (2019) (Web Link)

[5] Khatoon, M., Bindal, J., Chandra Sharma, D., Gupta, P., Singh Tomar, A., Saify, K. and Gupta, R. (2018) “Utility of Placental Umbilical Cord Blood in Autoimmune and Degenerative Disorders”, International Blood Research & Reviews, 8(4), pp. 1-9. doi: 10.9734/IBRR/2018/45260.(Web Link)

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