News Update on Blood Donor Research: May – 2019

Blood, sweat, and tears: Red Blood Cell‐Omics study objectives, design, and recruitment activities

BACKGROUND

The Red vegetative cell (RBC)‐Omics study was initiated to create an outsized knowledge set containing behavioural, genetic, and organic chemistry characteristics of blood donors with linkage to outcomes of the patients transfused with their given RBCs.

STUDY style AND strategies

The cohort was recruited from four U.S.A. blood centers. Demographic and donation knowledge were obtained from center records. A form to assess pica, restless leg syndrome, iron supplementation, secretion use, and emission and physiological state history was completed at enrollment. Blood was obtained for a whole blood count, DNA, and protein testing. A leukocyte‐reduced erythrocyte sample was transferred to a custom storage bag for hematolysis testing at Storage Days thirty-nine to forty two. A set was recalled to guage the dynamics and stability of hematolysis measures.

RESULTS

A total of thirteen,403 racially/ethnically numerous (12% African yank, 12% Asian, octavo Hispanic, 64% white, and fifth multiracial/other) donors of each sexes were listed and ranged from eighteen to ninety years of age; fifteenth were high‐intensity donors (nine or additional donations within the previous twenty four mo while not low hemoprotein deferral). knowledge parts are obtainable for ninety seven to ninety nine of the cohort.

CONCLUSIONS

The cohort provides demographic, behavioral, organic chemistry, and genetic knowledge for a broad vary of donor studies associated with iron metabolism, adverse consequences of iron deficiency, and differential hematolysis (including aerophilous and diffusion stress perturbations) throughout erythrocyte storage. Linkage to recipient outcomes might allow analysis of however donor characteristics have an effect on transfusion effectiveness. Repository DNA, plasma, and erythrocyte samples ought to expand the utility of this knowledge set. [1]

Frequent blood donations alter susceptibility of red blood cells to storage‐ and stress‐induced hemolysis

BACKGROUND

Frequent blood donations increase the prevalence of iron depletion in blood donors, which can afterward interfere with traditional biological process. the aim of this study was to judge the associations between donation frequency and red somatic cell (RBC) storage stability in an exceedingly racially/ethnically numerous population of blood donors.

STUDY style

Leukoreduced blood corpuscle concentrate–derived samples from thirteen,403 donors were hold on for thirty-nine to forty two days (1–6°C) then evaluated for storage, osmotic, and aerophilous haemolysis. Iron standing was evaluated by plasma protein measuring and self‐reported intake of iron supplements. Donation history within the previous a pair of years was obtained for every subject.

RESULTS

Frequent blood donors registered during this study were probably to be white, male, and of older age (56.1 ± 5.0 years). previous donation intensity was negatively related to aerophilous haemolysis (p < zero.0001) in variable analyses correcting for age, sex, and race/ethnicity. enlarged plasma protein concentration was related to increased blood corpuscle condition to every of the 3 measures of haemolysis (p < zero.0001 for all), whereas self‐reported iron intake was related to reduced condition to diffusion and aerophilous haemolysis (p < zero.0001 for both).

CONCLUSIONS

Frequent blood donations might alter the standard of blood elements by modulating blood corpuscle predisposition to haemolysis. RBCs collected from frequent donors with low protein have altered condition to haemolysis. Thus, frequent donation and associated iron loss might alter the standard of hold on blood corpuscle elements collected from iron‐deficient donors. any investigation is critical to assess posttransfusion safety and efficaciousness in patients receiving these blood corpuscle product. [2]

Frequent blood donation and offspring birth weight—a next‐generation association?

BACKGROUND

The prevalence of iron depletion is high among biological time girls WHO present blood oft. Studies in nondonor populations indicate that iron deficiency associateemia is related to an increased  risk of low birth weight. This prompts considerations that iron deficiency elicited by frequent blood donation may impair resultant foetal development.

STUDY style AND strategies

The aim of this study was to assess whether or not prepregnancy donation intensity affects the birth weight of singletons born at term (gestational week thirty eight or later) to nulliparous feminine donors in Scandinavian country. we tend to known 293,897 initial live singleton births to Danish girls between 1997 and 2012 with complete info on age, birth weight, child sex, parental age, maternal smoking standing throughout physiological state, and parental education length and annual financial gain. regression analysis was applied, with birth weight as outcome, range of donations among the three years before physiological state because the instructive  variable, and unsupportive variables as represented.

RESULTS

Birth weight among kids of low‐intensity donors (n = twenty two,120) was twelve.6 g (95% confidence interval, 6.7–18.6) on top of nondonors (n = 268,253) when dominant for the above‐mentioned factors. the upper birth weight among low‐intensity donors is explained by the healthy donor impact. In absolutely adjusted analyses, birth weight among kids of high‐intensity donors (n = three,524) was twenty.2 g (95% confidence interval, 5.1–35.3 g) lower compared with low‐intensity donors. This reduced birth weight

among high‐intensity donors compared to low‐intensity donors might replicate blood donation–induced iron deficiency.

CONCLUSIONS

Our results show that top prepregnancy donation intensity is reciprocally related to birth weight of singletons born at term to nulliparous girls.[3]

Seroprevalence of six pathogens transmitted by the Ixodes ricinus ticks in asymptomatic individuals with HIV infection and in blood donors

The objective of our study was to estimate the seroprevalence of six pathogens transmitted by ticks in HIV-infected persons and blood donors in European nation (B. burgdorferi s.l., A. phagocytophilum, Ehrlichia spp., Babesia spp., bacteria spp. Bartonella henselae) to assess the frequency of exposure to such microorganisms in immunocompetent and upset people in endemic regions for I. Ricinus ticks. bodily fluid samples were collected from 227 HIV-infected patients and 199 blood donors. All samples were analyzed for antibodies against six tick-borne pathogens and seroprevalence rates were statistically compared between 2 tested cluster further as age, sex and leukocyte T CD4+ level in HIV infected patients. The seroprevalence of tick-borne infections in HIV-infected patients is over that of the healthy population in European nation, though no association between serologic standing of patients and lymphocyte CD4+ lymph cell level has been discovered. The frequency of tick-borne coinfections and uncertain results of serologic tests were considerably higher in HIV-positive people. In Poland, the chance of tick-borne diseases transmission with blood is quite negligible.[4]

Seroprevalence of Cytomegalovirus (CMV) Amongst Voluntary Blood Donors in University of Benin Teaching Hospital (UBTH), Edo State, Nigeria

Aim: to analyze the seroprevalence of herpes virus (CMV) among voluntary blood donors in University of African nation Teaching Hospital (UBTH), Nigeria with the aim of determinative whether or not routine cytomegalovirus screening for donors is even or not.

Place and period of Study: Department of hematology and Department of Medical biological science, University of African nation Teaching Hospital (UBTH), Benin city, Nigeria, between could and Sep, 2010.

Methodology: Sera from every which way selected  100 and xcii (192) voluntary blood donors, consisting of 176 males associated sixteen females that visited the hospital from could to Sep 2010 were evaluated for CMV-IgG and IgM antibodies victimisation an enzyme-linked immunosorbent assay (ELISA) primarily based kit.

Results: Seroprevalence for CMV-IgG and IgM were ninety five.8% and 3.1% severally. All feminine donors (n=16) were positive for Ig. a complete of 114 out of 192 (59.4%) donors were at intervals the cohort of 30-39 years. A prevalence of one thousandth for cytomegalovirus Ig protein was determined in age bracket ≥50 years,

Conclusion: Routine screening of donors for CMV-IgG protein would quantity to waste of resources given the high prevalence of ninety five.8%. Periodic screening to spot the tiny proportion of seronegative blood donors (4.2%) UN agency are required for the ever increasing variety of immunological disorder recipients is suggested. [5]

Reference

[1]  Endres‐Dighe, S.M., Guo, Y., Kanias, T., Lanteri, M., Stone, M., Spencer, B., Cable, R.G., Kiss, J.E., Kleinman, S., Gladwin, M.T. and Brambilla, D.J., 2019. Blood, sweat, and tears: Red Blood Cell‐Omics study objectives, design, and recruitment activities. Transfusion, 59(1), pp.46-56. (Web Link)

[2] Kanias, T., Stone, M., Page, G.P., Guo, Y., Endres‐Dighe, S.M., Lanteri, M.C., Spencer, B.R., Cable, R.G., Triulzi, D.J., Kiss, J.E. and Murphy, E.L., 2019. Frequent blood donations alter susceptibility of red blood cells to storage‐and stress‐induced hemolysis. Transfusion, 59(1), pp.67-78. (Web Link)

[3] Rigas, A.S., Pedersen, O.B., Sørensen, E., Thørner, L.W., Larsen, M.H., Katz, L.M., Nielsen, K., Titlestad, K., Edgren, G., Rostgaard, K. and Erikstrup, C., 2019. Frequent blood donation and offspring birth weight—a next‐generation association?. Transfusion, 59(3), pp.995-1001. (Web Link)

[4] Seroprevalence of six pathogens transmitted by the Ixodes ricinus ticks in asymptomatic individuals with HIV infection and in blood donors

Agnieszka Pawełczyk, Małgorzata Bednarska, Justyna D. Kowalska, Beata Uszyńska-Kałuża, Marek Radkowski & Renata Welc-Falęciak

Scientific Reportsvolume 9, Article number: 2117 (2019) (Web Link)

[5] Ojide, C. K., Ophori, E. A., Eghafona, N. O. and Omoti, C. (2011) “Seroprevalence of Cytomegalovirus (CMV) Amongst Voluntary Blood Donors in University of Benin Teaching Hospital (UBTH), Edo State, Nigeria”, Journal of Advances in Medicine and Medical Research, 2(1), pp. 15-20. doi: 10.9734/BJMMR/2012/621. (Web Link)

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