News Update on Caffeine Consumption Research: June – 2019

Caffeine consumption

Scientific literature cites a good vary of values for caffein content in food product. The authors recommend the subsequent commonplace values for the United States: occasional (5 oz) eighty five mg for ground roast occasional, sixty mg for fast and three mg for decaffeinated; tea (5 oz): thirty mg for leaf/bag and twenty mg for instant; colas: eighteen mg/6 oz serving; cocoa/hot chocolate: four mg/5 oz; chocolate milk: four mg/6 oz; chocolate candy: one.5–6.0 mg/oz. Some product from the uk and Scandinavian country have higher caffein content. caffein consumption survey information area unit restricted. supported product usage and on the market consumption information, the authors recommend a mean daily caffein intake for U.S. customers of four mg/kg. Among children;’younger than eighteen years more matured World Health Organization area unit customers of caffeine-containing foods, the mean daily caffein intake is concerning one mg/kg. each adults and kids in Scandinavian country and United Kingdom have higher levels of caffein intake. [1]

Prospective study of caffeine consumption and risk of Parkinson’s disease in men and women

Results of case‐control studies and of a prospective investigation in men counsel that consumption of occasional might shield against the chance of Parkinson’s sickness, however the active constituent isn’t clear. to handle the hypothesis that alkaloid is protecting against Parkinson’s sickness, we tend to examined the link of occasional and alkaloid consumption to the chance of this sickness among participants in a pair of in progress cohorts, the Health Professionals’ Follow‐Up Study (HPFS) and also the Nurses’ Health Study (NHS). The study population comprised forty seven,351 men and eighty eight,565 ladies United Nations agency were freed from Parkinson’s sickness, stroke, or cancer at baseline. A comprehensive life vogue and dietary form was completed by the participants at baseline and updated each 2–4 years. throughout the follow‐up (10 years in men, sixteen years in women), we tend to documented a complete of 288 incident cases of Parkinson’s sickness. Among men, once adjustment for age and smoking, the relative risk of Parkinson’s sickness was zero.42 (95% CI: zero.23–0.78; p for trend < zero.001) for men within the high one‐fifth of alkaloid intake compared to those in the bottom one‐fifth. AN inverse association was conjointly ascertained with consumption of occasional (p for trend = zero.004), alkaloid from noncoffee sources (p for trend < zero.001), and tea (p for trend = zero.02) however not coffee. Among ladies, the link between alkaloid or occasional intake and risk of Parkinson’s sickness was U‐shaped, with the bottom risk ascertained at moderate intakes (1–3 cups of coffee/day, or the third quintile of alkaloid consumption). These results support a doable protecting impact of moderate doses of alkaloid on risk of Parkinson’s sickness. [2]

Effects of Cigarette Smoking, Caffeine Consumption, and Alcohol Intake on Fecundability

Data from the Ontano Farm Family Health Study were analyzed to see whether or not smoking, caffeine, or alcohol use among men and girls have an effect on fecundability (the monthly chance of conception). during this retrospective cohort study of farm couples in Ontano, Canada, the farm operator, husband, and better half completed questionnaires throughout 1991–1992, ylaiding data on a pair of,607 planned pregnancies that had occurred over the previous thirty years. Fecundability ratios were calculated victimization associate degree analog of the Cox proportional hazards model. butt smoking among ladies and men was related to shrunken fecundability (fecundability ratio=0.90, ninety fifth confidence interval (CI) zero 82–0.98 and fecundability ratio=0.88, 95% CI 0.81–0.95, respectively). caffein consumption of one hundred mg or less versus over one hundred mg in ladies and men wasn’t related to fecundability (fecundabilrty ratio=0.98, 95% CI 0.91–1.07 and fecundability ratio=1.05, 95% CI 0.97–1.14, respectively). Decreases were ascertained among ladies United Nations agency were occasional drinkers (fecundability ratio=0.92, 95% CI 0.84–1.00) and men United Nations agency were significant tea drinkers (fecundabilrty ratio=0.85, 95% CI 0.69–1.05), in spite of caffein content. Alcohol use among ladies and men wasn’t related to fecundability. These information square measure in keeping with previous studies of the adverse result of tobacco on fecundability in feminine smokers and recommend an impression of smoking among males. continuing analysis of occasional and tea is guaranteed to handle constituents apart from caffein. [3]

Effects of Adolescent Caffeine Consumption on Cocaine Sensitivity

Caffeine is that the most typically used psychoactive drug, and consumption by adolescents has up markedly in recent years. we tend to known the consequences of adolescent alkaloid consumption on cocain sensitivity and determined biology changes inside the nucleus accumbens (NAc) that will underlie caffeine-induced hypersensitivity to cocain. Male Sprague-Dawley rats consumed alkaloid (0.3 g/l) or water for twenty eight days throughout adolescence (postnatal day 28–55; P28–P55) or adulthood (P67–P94). Testing occurred within the absence of alkaloid throughout adulthood (P62–82 or P101–121). Cocaine-induced and quinpirole (D2 receptor agonist)-induced locomotion was increased in rats that consumed alkaloid throughout adolescence. Adolescent consumption of alkaloid conjointly increased the event of a conditioned place preference at a sub-threshold dose of cocain (7.5 mg/kg, i.p.). These behavioural changes weren’t determined in adults intense alkaloid for a similar amount of your time. saccharose preferences weren’t altered in rats that consumed alkaloid throughout adolescence, suggesting there aren’t any variations in natural reward. alkaloid consumption throughout adolescence reduced basal monoamine neurotransmitter levels and increased monoamine neurotransmitter unleash within the North Atlantic Council in response to cocain (5 mg/kg, i.p.). alkaloid consumption throughout adolescence conjointly enlarged the expression of the monoamine neurotransmitter D2 receptor, monoamine neurotransmitter transporter, and nucleoside A1 receptor and shrivelled nucleoside A2A receptor expression within the North Atlantic Council. Consumption of alkaloid throughout adulthood enlarged nucleoside A1 receptor expression within the North Atlantic Council, however no different supermolecule expression changes were determined. along these findings recommend that alkaloid consumption throughout adolescence created changes within the North Atlantic Council that area unit evident in adulthood and should contribute to will increase in cocaine-mediated behaviors. [4]

Coffee and Caffeine Consumption in Reproductive Functions of Adult Wistar Rats

Coffee from coffee tree may be a standard food consumed worldwide. Its impact on health has been a world puzzle. during this study, the impact of low and alkaloid consumption on some procreative structures and functions of Wistar rats were investigated. 100 and 75 (175) Wistar rats bred within the Animal house of the college of Basic bioscience of Delta State University were used for this study. All experimental rats were treated for four (4) weeks. Group 1, control, received food and water solely, groups 2, three and four received forty mg/kg, sixty mg/kg and eighty mg/kg, doses of low severally whereas teams five, half-dozen and seven received thirty mg/kg, forty five mg/kg and sixty mg/kg doses of alkaloid severally. once administration of check substances, animals were sacrificed consequently with blood serum samples collected. whereas testes, neural structure and hippocampus were harvested for histologic studies, blood serum samples were analysed for specific parameters. In Unit 2 (2) 75 (75) rats of each sexes were mated and treated in varied coupling and treatment teams consequently till once gestation. Then, the weight, litter size, survival rate and gestation length were measured. each alkaloid and occasional treatments showed a dose-dependent impact on most parameters measured. low was found to extend inhibitor enzymes, decrease liver enzymes and conjointly negatively affected procreative outcome. All comparisons were done at (P≤0.05), exploitation 1-tailed ANOVA. [5]

Reference

[1] Barone, J.J. and Roberts, H.R., 1996. Caffeine consumption. Food and chemical toxicology, 34(1), pp.119-129. (Web Link)

[2] Ascherio, A., Zhang, S.M., Hernán, M.A., Kawachi, I., Colditz, G.A., Speizer, F.E. and Willett, W.C., 2001. Prospective study of caffeine consumption and risk of Parkinson’s disease in men and women. Annals of Neurology: Official Journal of the American Neurological Association and the Child Neurology Society, 50(1), pp.56-63. (Web Link)

[3] Curtis, K.M., Savitz, D.A. and Arbuckle, T.E., 1997. Effects of cigarette smoking, caffeine consumption, and alcohol intake on fecundability. American journal of epidemiology, 146(1), pp.32-41. (Web Link)

[4] Effects of Adolescent Caffeine Consumption on Cocaine Sensitivity

Casey E O’Neill, Sophia C Levis, Drew C Schreiner, Jose Amat, Steven F Maier & Ryan K Bachtell

Neuropsychopharmacology volume 40, pages 813–821 (2015) (Web Link)

[5] Esegbue, P. R. C., Aigbiremolen, A. A., Akindele, R. A., Ehiwe, O. D., Odigie, O. M., Naiho, A. O., & Igweh, J. C. (2017). Coffee and Caffeine Consumption in Reproductive Functions of Adult Wistar Rats. International Journal of Biochemistry Research & Review, 20(2), 1-11. https://doi.org/10.9734/IJBCRR/2017/30912 (Web Link)

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