News Update on Carcinosarcoma Research: April – 2019

Carcinosarcoma

Carcinosarcoma is associate degree extremely rare malignancy that affects adults and presents at a mean age of roughly sixty years. girls are concerned but men. the bulk of cases involve major secretion glands, presenting as single or multiple plenty. Most cases of malignant tumor behave as top-grade malignancies. malignant tumor is infiltrative and comprised of malignant neoplastic disease and heterologous sarcomatous components [1]

Pilomatrical carcinosarcoma of the temple: A case report

Pilomatrical malignant neoplasm may be a terribly rare entity, with solely six cases reported  yet. This report describes the case of a 100‐year‐old girl with a mass on the left temple that had existed for many decades however had recently fully grown in size. Associate in Nursingatomy} showed an uneven lesion composed of basaloid cells, spindle cells, and “shadow” or “ghost” cells. Cells had atypical hyperchromatic nuclei with distinguished nucleoli, high mitotic activity, and atypical cellular division. within the central space, Associate in Nursing epidermic cyst‐like structure was seen. The identification of pilomatrical malignant neoplasm was rendered. This case gave the impression to have arisen from malignant transformation of a pilomatricoma due to the long clinical history and existence of a benign epidermic cyst‐like structure. additionally, the observation that the basaloid cells and spindle cells showed a gradual transition from one to the opposite which each varieties were positive for β‐catenin would appear to support a typical organism origin for the cancer and sarcomatous parts. [2]

Primary peritoneal carcinosarcoma: A report of two cases

Objective

Carcinosarcomas additionally referred to as malignant mixed mullerian tumors (MMMTs) contain each malignant neoplastic disease and sarcomatous components. Most MMMTs are arising from feminine reproductive organ tract, together with ovaries, womb and fallopian tubes. Extragenital carcinosarcomas are very rare, with an estimation but forty cases to this point.

Case report

We report 2 cases of primary serous membrane carcinosarcomas. associate 81-year-old girl with girdle serous membrane malignant tumor, heterologous sort, was treated with incomplete surgery while not additional therapy, and died of unwellness shortly. the opposite one was a seventy six year-old girl with abdominal serous membrane malignant tumor, homologous sort. when optimum debulking surgery and resulting half-dozen cycles of combination of paclitaxel and carboplatin therapy, the patient is freed from growth 1/2 year.

Conclusion

Active medical aid, together with complete cytoreduction surgery and carboplatin-paclitaxel therapy may provide an opportunity of unwellness management for these uncommon primary serous membrane carcinosarcomas. [3]

Prostatic carcinosarcoma 15 years after combined external beam radiation and brachytherapy for prostatic adenocarcinoma: a case report

A 65-year-old man with a history of combined girdle external beam actinotherapy (EBRT) and brachytherapy for glandular carcinoma fifteen years previous underwent total pelvic operation for plausible body part cancer with endocrine invasion. Pathology disclosed metastatic tumor of endocrine origin. This patient exhibited the longest rumored interval between initial presentation with glandular carcinoma and development of metastatic tumor. This case is additionally the primary rumored case of endocrine metastatic tumor occurring once combined EBRT and brachytherapy. The increasing use of such combination high-dose actinotherapy could doubtless cause AN inflated incidence of secondary malignancies like endocrine metastatic tumor within the future. [4]

Phytotherapeutic Molecules & Antioxidants: A Novel & Secure Approach of Cancer Prevention

Cancer is that the second leading explanation for death worldwide. though nice advancements are created within the treatment and management of cancer progression, important deficiencies and space for improvement stay. variety of unwanted facet effects like vomit, hair loss, immunosupression, radical formation etc. occur throughout therapy. Free radicals are the explanation for aerobic  stress, which can causes injury to cells, genetic mutation, and will result in cancer. aerobic  stress can even causes cancer, by the interaction with animate thing signal transduction and transcription factors, directly or indirectly. Associate in Nursing inhibitor is any substance that delays, prevents or removes aerobic  harm to a target molecule. this may be achieved by the doorway of drugs like phytotherapeutic molecules, chemical reaction inhibitors, vitamins, minerals, within the body from completely different natural sources. These compounds neutralize the free radicals and forestall from excessive production of harmful parts within the body. Phytotherapeutic molecules are the secondary metabolites that hold the promise to style new medication in drug development method for treatment of heap of diseases like cancer. This review is try to screen and explore the role of phytotherapeutic molecules and aerobic  inhibitors as novel and secures approach of antitumor and chemo-preventive agents. There are many natural therapies accessible in ancient drugs system like therapy, therapy etc. to forestall and generally cure the cancer. The herbs, spices, vegetables & fruits are the wealthy supply of phytotherapeutic molecules and antioxidants that are powerfully active against carcinogenesis. [5]

Reference

[1] García, J.J., 2019. Carcinosarcoma. In Atlas of Salivary Gland Pathology (pp. 79-83). Springer, Cham. (Web Link)

[2] Mori, D., 2019. Pilomatrical carcinosarcoma of the temple: A case report. Journal of cutaneous pathology, 46(4), pp.267-270. (Web Link)

[3] Fu, H.S., Wu, Y.C., Chen, C.H., Liu, W.M., Cheng, C.J., Chang, C.W., Wang, I.D. and Chiu, Y.H., 2019. Primary peritoneal carcinosarcoma: A report of two cases. Taiwanese Journal of Obstetrics and Gynecology, 58(2), pp.288-291. (Web Link)

[4] Prostatic carcinosarcoma 15 years after combined external beam radiation and brachytherapy for prostatic adenocarcinoma: a case report.

T Y Tseng, D W Sevilla, J W Moul & K E Maloney

Prostate Cancer and Prostatic Diseases volume 9, pages 195–197 (2006)(Web Link)

[5] Sharma, V., Katiyar, A. and Agrawal, R. C. (2015) “Phytotherapeutic Molecules & Antioxidants: A Novel & Secure Approach of Cancer Prevention”, Annual Research & Review in Biology, 7(4), pp. 249-260. doi: 10.9734/ARRB/2015/18862.(Web Link)

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