Press Release on Aneurysms Research: September-2018

Asthma drug potential treatment for an aortic aneurysm

An aortic aneurysm — the dilation of the arterial blood vessel — could be a serious condition that lacks effective drug treatment. Researchers at Karolinska Institutet in Sweden report within the journal PNAS, however, that a typical respiratory disorder drug will retard the event of an aneurysm in mice.

“Our results are exciting and open the means for a medical treatment of this serious tube-shaped structure malady,” says faculty member Jesper Z. Haeggström at Karolinska Institutet’s Department of Medical organic chemistry and natural philosophy. [1]

Devices and methods for treating aneurysms and other vascular conditions

A fenestrated artery cuff is designed to be delivered endovascularly to a target region, deployed, fastened, and sealed to a vessel wall, e.g., during an exceedingly|in a very} neck region of an aneurysm. Example fenestrated cuffs offer an acceptable landing zone for a commercially obtainable endograft, which can be, in some cases, positioned below or on top of the nephritic arteries so as to complete exclusion of AN abdominal aneurysm (AAA) or a pectoral aneurysm (TAA), severally, from systematic circulation. [2]

Advances in aneurysm treatment with a focus on middle cerebral artery aneurysms and delayed cerebral ischemia

In this thesis completely different aspects of aneurysmal subarachnoid hemorrhage (aSAH) square measure investigated with a stress on middle arteria cerebri (MCA) cardiovascular disease treatment outcome, hemorrhage volume quantification on completely different locations, and delayed cerebral anemia (DCI). First, the literature is reviewed to check the clinical and imaging outcome of clipping and voluted of MCA aneurysms. [3]

Strongly Coupled Morphological Features of Aortic Aneurysms Drive Intraluminal Thrombus.

Over seventy-fifth of abdominal artery Associate in Nursingeurysms harbor an intraluminal clot, and increasing proof suggests that biologically active clot contributes to the explanation of those doubtless deadly lesions. clot formation depends on the native hemodynamics, that successively depends on morphological options of an aneurysm and closes to the vasculature. we tend to antecedently confer a hemodynamically actuated “thrombus kindation potential” that predicts wherever and once clot may form. Herein, we tend to mix elaborate studies of the three-dimensional hemodynamics with strategies of distributed grid collocation and interpolation via kriging to look at roles of 5 key morphological options of aneurysms on clot formation: lesion diameter, axial position, length, curvature, and arterial position. [4]

Sinus of Valsalva Aneurysms in Non-Marfan Patients: An Underestimated Entity? A Case Series

Aims: Sinus of Valsalva aneurysms are rare anomalies. cardiovascular disease dilatation of the sinuses of Valsalva in Marfan syndrome has been extensively studied. The aim of this study was to research clinical manifestation, diagnosis, histopathological findings and management of sinus of Valsalva aneurysms in non-Marfan patients.

Study Design: Retrospective analysis, case-series.

Methodology: a groundwork of digital echocardiographic recordings, histopathology and electronic patient databases in our establishment for the amount 2004 – 2012 was performed. All patients with asymmetrical dilatation of a minimum of one sinus of Valsalva at postmortem and busted (or dissected) aneurysms on sonogram were enclosed. [5]

Reference

[1] Asthma drug potential treatment for an aortic aneurysm

Date: February 6, 2018, Source: Karolinska Institutet (web link)

[2] Devices and methods for treating aneurysms and other vascular conditions

Bolduc L, Muhs B, inventors; Medtronic Vascular Inc, assignee. Devices and methods for treating aneurysms and other vascular conditions. The United States patent application US 15/956,642. 2018 Aug 23. (web link)

[3] Advances in aneurysm treatment with a focus on middle cerebral artery aneurysms and delayed cerebral ischemia

Zijlstra I. Advances in aneurysm treatment with a focus on middle cerebral artery aneurysms and delayed cerebral ischemia. (web link)

[4] Strongly Coupled Morphological Features of Aortic Aneurysms Drive Intraluminal Thrombus.

Bhagavan D, Di PA, Humphrey JD. Strongly Coupled Morphological Features of Aortic Aneurysms Drive Intraluminal Thrombus. Scientific reports. 2018 Sep;8(1):13273-. (web link)

[5] Sinus of Valsalva Aneurysms in Non-Marfan Patients: An Underestimated Entity? A Case Series

Maryanne Caruana1*, Mary N. Sheppard2, and Wei Li1

1Adult Congenital Heart Disease Unit, Royal Brompton Hospital, Sydney Street, London SW3 6NP, United Kingdom.

2Imperial Cardiac Pathology Unit, Royal Brompton Hospital, Sydney Street, London SW3 6NP, United Kingdom. (web link)

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