Press Release on Antimicrobial Research: September-2018

Artificial antimicrobial peptides could help overcome drug-resistant bacteria

Researchers have currently developed an efficient approach to developing artificial antimicrobial peptides. Their strategy, that depends on a laptop algorithmic rule that mimics the action of evolution, has yielded one potential drug candidate that with success killed bacterium in mice. [1]

Microbial transformations of 4′-methyl chalcone as an efficient method of obtaining novel alcohol and dihydrochalcone derivatives with antimicrobial activity

Biotransformations are an alternative method of receiving dihydrochalcones as a result of the reduction of α,β-unsaturated ketones – chalcones. In the conferred analysis, 2 strains of microorganism – Gordonia sp. DSM44456 and Rhodococcus sp. DSM364 – were elected as effective biocatalysts that arable to remodel chalcones in a very short amount of your time. As a result of our investigation, three new dihydrochalcones and one novel alcohol were obtained with high isolated yields. All 4′-methyl chalcone derivatives and biotransformations products were tested for antimicrobial activity against Escherichia coli ATCC10536, staph aureus DSM799, candida DSM1386, Alternaria alternate CBS1526, Fusarium linii KB-F1, and Aspergillus niger DSM1957. [2]

Knowledge, attitude, perception, and practice towards antimicrobial use in upper respiratory tract infections in Qatar: a systematic review

Background: The emergence and unfold of resistance relating to the inappropriate use of antimicrobials may be a world public pathological state. a considerable proportion of all antimicrobials area unit prescribed within the community, and higher tract Infection (URTI) is one in all the most typical conditions in health care settings that antimicrobial prescriptions area unit wide used. we have a tendency to assessed information, attitude, perception and apply towards antibiotic use for URTIs in patients visiting healthcare settings in Qatar. Aim: To explore the information, attitude, perception and apply towards antimicrobial use in higher tract infections in patients visiting healthcare settings in Qatar. Methodology: the Systematic review was performed employing a preset protocol and in accordance with standardized coverage tips. MEDLINE, PubMed, EMBASE, world Health, and PsycINFO were a probe for relevant revealed studies mistreatment relevant MESH terms and keywords. Results: 3 articles were enclosed, one in an exceedingly medical aid setting, one in an exceedingly secondary care setting and one within the non-public sector. [3]

Engineered Polymer Nanoparticles with Unprecedented Antimicrobial Efficacy and Therapeutic Indices Against Multidrug-Resistant Bacteria and Biofilms

The speedy emergence of antibiotic-resistant microorganism “superbugs” with concomitant treatment failure and high mortality rates presents a severe threat to world health. The poinsettia strain risk is any exacerbated by chronic infections generated from antibiotic-resistant biofilms that render them refractory to accessible treatments. we tend to hypothesize that economical antimicrobial agents can be generated through careful engineering of hydrophobic and ion domains in a very artificial semi-rigid chemical compound scaffold, mirroring and amplifying attributes of antimicrobial peptides. [4]

Screening for Antimicrobial Activity of Cissampelos pareira L. Methanol Root Extract

Aims: To screen for the medicine activity of Cissampelos pareira L. victimization six microorganisms (Two Gram-positive microorganisms (Staphylococcus aureus and microorganism pneumonia) and 4 Gram-negative bacteria (Escherichia coli, genus Pseudomonas aeroginosa, enteric bacteria pneumonia and Proteus Vulgaris). The phytochemicals that are answerable for the bioactivity were additionally screened.

Study Design: Associate in Nursing In vitro medicine assay was done by victimization disc diffusion.

Place and period of Study: Samples were collected from the Mbeere community, Embu County-Kenya. Authentication of biology identity was done at the department of biological sciences whereas extraction and phytochemical analysis were undertaken within the Department of Chemistry, Egerton University-Kenya. An antimicrobial bioassay was distributed at Department of biological science, valley Provincial General Hospital. [5]

Reference

[1] Artificial antimicrobial peptides could help overcome drug-resistant bacteria

Date: April 16, 2018, Source: Massachusetts Institute of Technology (web link)

[2] Microbial transformations of 4′-methyl chalcone as an efficient method of obtaining novel alcohol and dihydrochalcone derivatives with antimicrobial activity

Kozłowska J, Potaniec B, Żarowska B, Anioł M. Microbial transformations of 4′-methyl chalcone as an efficient method of obtaining novel alcohol and dihydrochalcone derivatives with antimicrobial activity. RSC Advances. 2018;8(53):30379-86. (web link)

[3] Knowledge, attitude, perception and practice towards antimicrobial use in upper respiratory tract infections in Qatar: a systematic review

Shaikhan F, Rawaf S, Majeed A, Hassounah SO. Knowledge, attitude, perception, and practice towards antimicrobial use in upper respiratory tract infections in Qatar: a systematic review. (web link)

[4] Engineered Polymer Nanoparticles with Unprecedented Antimicrobial Efficacy and Therapeutic Indices Against Multidrug-Resistant Bacteria and Biofilms

Gupta A, Landis RF, Li CH, Schnurr M, Das R, Lee YW, Yazdani M, Liu Y, Kozlova A, Rotello VM. Engineered Polymer Nanoparticles with Unprecedented Antimicrobial Efficacy and Therapeutic Indices Against Multidrug-Resistant Bacteria and Biofilms. Journal of the American Chemical Society. 2018 Aug 31. (web link)

[5] Screening for Antimicrobial Activity of Cissampelos pareira L. Methanol Root Extract

Njeru S. Ngoci1*, Musa Ramadhan2, Mwaniki S. Ngari3,5, and Oduor P. Leonard4

1Department of Medicine, Kisii University, Faculty of Health Sciences, PO Box 408, Kisii, Kenya.

2Department of Pathology, Rift Valley Provincial General Hospital, PO Box 71, Nakuru, Kenya.

3Department of Chemistry, Kisii University, Faculty of Science, PO Box 408, Kisii, Kenya.

4Department of Biological Sciences, Egerton University, PO Box 536, Egerton, Kenya.

5Department of Chemistry, Egerton University, PO Box 536, Egerton, Kenya. (web link)

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