Press Release on Placebo Research: September-2018

Placebo pills prescribed honestly help cancer survivors manage symptoms

Long when cancer treatment ends, several still influence one specific symptom that refuses to travel away: fatigue. in a very new study, researchers at the University of Alabama at Birmingham and Harvard graduate school have found that the facility of placebos, even once totally disclosed to patients, may be controlled to cut back fatigue in cancer survivors.

For cancer survivors, few treatments are on the market to alleviate fatigue when treatment, and therefore the simplest medical specialty interventions go along with side-effect warnings that embrace panic, mental disease, and a heart condition. [1]

Placebo effects in adult and adolescent patients with schizophrenia: a combined analysis of nine RCTs

Objective: to look at characteristics of placebo responders and ask for optimum criteria for early improvement with placebo for predicting sequent placebo response in patients with psychosis.

Method: Data from 672 patients with schizophrenia randomized to placebo in nine double‐blind antipsychotic trials were analyzed. Multiple logistical regression analyses were conducted to look at associations between placebo response at week half-dozen (i.e., a ≥ 25% reduction in the Positive and Negative Syndrome Scale [PANSS] score) and gender, age, study locations, baseline PANSS total or Marder 5‐Factor scores, and percent PANSS score reduction at week one. [2]

Effects of high-dose baclofen on cue reactivity in alcohol dependence: A randomized, placebo-controlled pharmaco-fMRI study

Increased useful brain response towards alcohol-associated stimuli could be a neural hallmark of alcohol dependence and a promising target for pharmacotherapy. For the primary time, we tend to assess the results of singly titrated high-dose baclofen on cue reactivity and useful property in an exceedingly cool-dependent (AD) patients in a randomized controlled trial (RCT).

We investigated twenty-three recently detoxified AD patients and twenty-three matched healthy controls (HC) with a cue reactivity useful resonance imaging task. Patients were more scanned at baseline while not medication and through treatment with high-dose baclofen/placebo (30–270 mg/d). Analyses were conducted for alcohol cue-elicited brain response, alcohol cue-modulated and stimulus-independent useful property with left ventral tegmental space (VTA) as seed region. [3]

A randomized blind placebo-controlled trial investigating the effects of photobiomodulation therapy (PBMT) on canine elbow osteoarthritis.

The result of photobiomodulation medical care (PBMT) or sham light-weight medical care on pain, NSAID drug (NSAID) demand, and gimpiness was studied in twenty dogs with present elbow degenerative arthritis. Dogs (n = 20) were haphazardly assigned  to receive either PBMT (group PBMT; n = 11) ten to twenty J/cm2 or a placebo treatment (sham light-weight cluster S; n = 9) treatment zero J/cm2, to each elbows for six weeks. gimpiness score, pain score, and anti-inflammatory dose were recorded by blind study personnel before and seven to ten days when last treatment. Reduction in anti-inflammatory dose occurred in 9/11 dogs within the PBMT cluster and in zero/9 of cluster S dogs (P = 0.0003). [4]

A Randomized Placebo-Controlled Study to Determine the Efficacy of Oral Diclofenac Sodium in the Treatment of Symptomatic Osteoarthritis of the Knee in Nnewi, South Eastern Nigeria

Background: medicinal drug|NSAID} could be a non-selective non-steroidal anti-inflammatory drug (NSAID) that’s wide used therapeutically for its analgesic and anti-inflammatory properties within the treatment of knee arthritis (KOA) however no scientific study has been dispensed at Nnewi, a city settled within the Southeastern a part of Federal Republic of Nigeria to work out its therapeutic effectivity. the aim of this study was to work out the effectivity of oral NSAID within the treatment of KOA within the native population victimization genu pain intensity, extensor muscle strength and thirty.4 meters walk-time as outcome measures. [5]

Reference

[1] Placebo pills prescribed honestly help cancer survivors manage symptoms

Date: February 9, 2018, Source: the University of Alabama at Birmingham (web link)

[2] Placebo effects in adult and adolescent patients with schizophrenia: a combined analysis of nine RCTs

Kubo K, Fleischhacker WW, Suzuki T, Yasui‐Furukori N, Mimura M, Uchida H. Placebo effects in adult and adolescent patients with schizophrenia: a combined analysis of nine RCT s. Acta Psychiatrica Scandinavica. 2018 Sep 9. (web link)

[3] Effects of high-dose baclofen on cue reactivity in alcohol dependence: A randomized, placebo-controlled pharmaco-fMRI study

Beck A, Pelz P, Lorenz RC, Charlet K, Geisel O, Heinz A, Wüstenberg T, Müller CA. Effects of high-dose baclofen on cue reactivity in alcohol dependence: A randomized, placebo-controlled pharmaco-fMRI study. European Neuropsychopharmacology. 2018 Sep 11. (web link)

[4] A randomized blind placebo-controlled trial investigating the effects of photobiomodulation therapy (PBMT) on canine elbow osteoarthritis.

Looney AL, Huntingford JL, Blaeser LL, Mann S. A randomized blind placebo-controlled trial investigating the effects of photobiomodulation therapy (PBMT) on canine elbow osteoarthritis. The Canadian veterinary journal= La revue veterinary Canadienne. 2018 Sep;59(9):959. (web link)

[5] A Randomized Placebo-Controlled Study to Determine the Efficacy of Oral Diclofenac Sodium in the Treatment of Symptomatic Osteoarthritis of the Knee in Nnewi, South Eastern Nigeria

Chima Collins Ihegihu1*, Ebere Yvonne Ihegihu2, Afamefuna Victor Egwuownu3, and Joseph Onuwa Umunnah3

1Department of Orthopaedics and Trauma Surgery, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Nigeria.

2Department of Physiotherapy, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Nigeria.

3Department of Medical Rehabilitation, Nnamdi Azikiwe University, Nnewi Campus, Nigeria. (web link)

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