Research Update on Anemia Research: February -2019

Nivolumab-induced aplastic anemia: A case report and literature review

Directed therapy at the programmed cell death-1 receptor has incontestable  effectiveness in non-small-cell carcinoma, pathological process malignant melanoma, and numerous different malignancies. Immune stop inhibitors are innovative therapies manufacturing some spectacular clinical responses with a a lot of manageable adverse impact profile in comparison to ancient therapy. The a lot of common adverse effects related to these agents embrace fatigue, rash, myalgia, pyrexia, and cough, however less common nevertheless serious adverse effects have enclosed immune-mediated rubor, inflammation, hepatitis, sort one polygenic disorder, and cephalitis. Here we tend to gift a case of a feminine patient with spongioblastoma multiforme, United Nations agency was treated with the programmed cell death-1 receptor substance nivolumab and after developed aplastic anaemia. [1]

Total dose iron dextran infusion versus oral iron for treating iron deficiency anemia in pregnant women: a irregular controlled trial

Study objective: To check safety, efficacy, and cost-effectiveness of total dose infusion (TDI) of low relative molecular mass (LMW) iron dextran for treatment of iron deficiency anemia (IDA) throughout physiological condition compared to oral metal fumarate.

Design: Prospective interventional randomised controlled trial (RCT). style classification. Canadian Task Force II3.

Setting: Prenatal  clinic and relation unit of a tertiary care referral facility and University Hospital.

Patients: A complete sixty six anemic pregnant ladies (hemoglobin level between 7–10 g/dl).

Intervention: Administration of a LMW iron dextran as a TDI (group A) or Oral iron metal fumarate 60 mg elemental iron thrice daily (group B) followed by remeasurement of Hb once four weeks. [2]

The molecular genetics of sideroblastic anemia

The sideroblastic anemias (SAs) are a bunch of transmissible and purchased bone marrow disorders outlined by pathological iron accumulation within the mitochondria of blood cell precursors. Like most medicine diseases, the molecular genetic basis of the SAs has ridden the wave of technology advancement. at intervals the last thirty years, with the appearance of point biological research, the human ordering project, solid-state genotyping technologies, and next-generation sequencing have evolved to the purpose wherever over common fraction of nonheritable Sturmarbeiteilung cases, and a fair bigger proportion of cases of nonheritable organism unwellness, will be attributed to mutations in an exceedingly specific factor or genes. This review focuses on Associate in Nursing analysis of the biological science of those diseases and the way understanding these defects might contribute to the look and implementation of rational therapies. [3]

Early test knowledge show cistron medical care reversing RBC anemia

After over a decade of diagnosis analysis and development, a replacement sequence medical care treatment for RBC anemia (SCA) is reversing illness symptoms in 2 adults and showing early potential for transportability to resource-challenged elements of the planet wherever SCA is commonest. [4]

Management of Odontogenic symptom in Patients with erythrocyte Anemia: five Case Reports

Sickle cell anemia (SCA) may be a hereditary disorder characterised by a defect within the red vegetative cell (RBC) Hb molecule leading to a diminished ability for the blood to hold chemical element and a bent for the blood to clump. Clinical manifestations of SCA, aside from the vasoocclusive complications are increasing condition to infection, and chronic anemia from each lysis of the reaping hook cells. 5 patients with age starting from fourteen to twenty seven years; bestowed to the service of medicine, Mixed medication Center and SS Anemia (MMCSA), Kinshasa/DR. Congo with a history of pain and swelling within the submaxilla and/or jaw regions of many days period. All five patients were diagnosed with odontogenic abscesses. as a result of any infection during a patient with SS sickness will become dangerous, we tend to present these case reports to signalize to the current significant issue and share our clinical management and knowledge, particularly with surgeons United Nations agency apply in areas with restricted resources. additionally, we tend to review the signs, symptoms, diagnosis, and surgical management of odontogenic infection. [5]

Reference

[1] Comito RR, Badu LA, Forcello N. Nivolumab-induced aplastic anemia: a case report and literature review. Journal of Oncology Pharmacy Practice. 2019 Jan;25(1):221-5. (web link)

[2] Darwish AM, Khalifa EE, Rashad E, Farghally E. Total dose iron dextran infusion versus oral iron for treating iron deficiency anemia in pregnant women: a randomized controlled trial. The Journal of Maternal-Fetal & Neonatal Medicine. 2019 Feb 1;32(3):398-403. (web link)

[3] Ducamp S, Fleming MD. The molecular genetics of sideroblastic anemia. Blood. 2019 Jan 3;133(1):59-69. (web link)

[4] Early clinical trial data show gene therapy reversing sickle cell anemia

Date: December 4, 2018

Source: Cincinnati Children’s Hospital Medical Center (web link)

[5] Management of Odontogenic Abscess in Patients with Sickle Cell Anemia: 5 Case Reports

Mutombo Mutombo Alphonse

Research Sciences and Health Institute of Kinshasa, Kinshasa, DR Congo

Nyimi Bushabu Fidele

Oral and Maxillofacial Surgery, Department of Dental Medicine, Affiliated Hospital of Kinshasa University, Kinshasa, DR Congo

Kanyana Makolo Dany

Research Sciences and Health Institute of Kinshasa, Kinshasa, DR Congo

Ngueji Kakubu Olivier

Department of Pediatrics, General Reference Hospital of Kintambo, Kinshasa, DR Congo

Mantshumba Milolo Augustin

Prosthodontics and Orthodontics Service, Department of Dental Medicine, Affiliated Hospital of Kinshasa University, Kinshasa, DR Congo

Suwal Rubina

Department of Oral and Maxillofacial Surgery, Second Affiliated Hospital of Jiamusi University, Heilongjiang, China (web link)

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