QSAR Investigation on 3,5-diaryl-4,5-dihydro-1H-pyrazole-1-carbothioamides as EGFR Kinase Inhibitors
In order to establish a quantitative relationship between epidermal growth factor receptor (EGFR) kinase inhibitory activity and physicochemical / structural properties, a quantitative structure activity...
Study on Synthesis and Appraisal of Some 2,5-Disubstituted-1,3,4-Thiadiazoles as Diuretic Agents
Acetazolamide and Methazolamide are diuretic 1,3,4-thiadiazole compounds that are well-known. As a result, certain novel 2,5-disubstituted-1,3,4-thiadiazoles were synthesised and diuretic efficacy was tested. The diuretic...
Study on 1, 3, 4-Oxadiazole Derivatives as an Antibacterial and Antifungal Agents
A new series of 1, 3, 4-oxadiazoles (3a-j) was synthesised in this study by reacting INH (1) with substituted aromatic acids (2) in the presence...
Determining the Effect of 1, 3, 5-trimethyl-2, 6-diphenyl Piperidin-4-one Oxime on the Electrochemical Behaviour of Mild Steel in HCl Medium
The corrosion inhibitory capacity of a synthetic heterocyclic molecule, namely 1, 3, 5-trimethyl-2, 6-diphenyl piperidin-4-one oxime, was evaluated using weight loss experiments, electrochemical methods, and...
Study on Synthesis and Characterization of New 8- Trifluloromethyl Quinazolin-2,4-(3H)-Dione Nucleosides
The synthesis of 8-trifluloromethyl quinazolin-2,4-(1H,3H)-dione 2, which was ribosylated by coupling with 1-O-acetyl-2,3,5-tri-O-benzoyl—D-ribofuranose 4 via the silylation method, yielded mixture and -anomeric benzoylated nucleoside derivatives...
Isolation, Characterizations of Bioactive Principles from Melia dubia Leaf and Its In-silico and In-vitro Urolithiatic Activity
Many medicinal plants contain a wide range of bioactive compounds at various levels. The primary goal of this research is to identify and separate antioxidants...