Synthesis and Antitumor Evaluation of Some New Derivatives and Fused Heterocyclic Compounds Derived from Thieno[2,3‐ b]pyridine: Recent Perspective

Posted on July 29, 2020Categories ChemistryTags , , , , , , , , , ,   Leave a comment on Synthesis and Antitumor Evaluation of Some New Derivatives and Fused Heterocyclic Compounds Derived from Thieno[2,3‐ b]pyridine: Recent Perspective

As a continuation of our research on developing anticancer agents and based on the proven proprieties of thieno[2,3‐b]pyridines as anticancer, we have designed to synthesize novel thieno[2,3‐ b]pyridine derivatives that incorporate different biologically active heterocycles through various chemical reactions. All of the newly obtained compounds, compared with the standard anticancer drug (doxorubicin), were screened in vitro for their antitumor activity against hepatocellular carcinoma (HepG‐2) and human breast cancer (MCF‐7) cell lines. The results revealed that compounds 3, 7, 12, and … Continue reading “Synthesis and Antitumor Evaluation of Some New Derivatives and Fused Heterocyclic Compounds Derived from Thieno[2,3‐ b]pyridine: Recent Perspective”