Lycopodium Alkaloids from Vietnamese Huperzia squarrosa (Forst.) Trevis and Their Anti-cholinesterase Activity

Posted on February 13, 2021Categories Chemistry and BiochemistryTags , , , ,   Leave a comment on Lycopodium Alkaloids from Vietnamese Huperzia squarrosa (Forst.) Trevis and Their Anti-cholinesterase Activity

Vietnamese Huperzia squarrosa was isolated from a sequence of lycopodium alkaloids, namely lycosquarosine A (1), acetylaposerratinine (2), huperzine A (3), huperzine B (4), 8pha-hydrophlemariurine B (5) and huperzinine (6). Among them, the latest natural source metabolite is lycosquarosine A (1). Dose-dependent AChE activity was completely inhibited by lycosquarosine A with an IC50 value of 54.3 μg/mL, while acetylposerratinine (2) displayed greater inhibitory activity than 1 with an IC50 value of 15.2 μg/mL. This outcome suggests that AChE inhibitors may be … Continue reading “Lycopodium Alkaloids from Vietnamese Huperzia squarrosa (Forst.) Trevis and Their Anti-cholinesterase Activity”